Neuac Side Effects Center

Last updated on RxList: 1/19/2021
Neuac Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Neuac?

Neuac (clindamycin phosphate and benzoyl peroxide) Gel, 1.2%/5% is a combination of an antibiotic and an antibacterial and drying agent indicated for the topical treatment of inflammatory acne vulgaris.

What Are Side Effects of Neuac?

Common side effects of Neuac Gel include:

  • skin redness,
  • peeling,
  • burning, and
  • dryness.

Dosage for Neuac

Neuac Gel should be applied once daily, in the evening or as directed by the physician, to affected areas after the skin is gently washed, rinsed with warm water and patted dry.

What Drugs, Substances, or Supplements Interact with Neuac?

Neuac Gel may interact with other drugs. Tell your doctor all medications and supplements you use.

Neuac During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Neuac Gel; it is unknown if it would harm a fetus. It is unknown if Neuac Gel passes into breast milk after topical application. Oral clindamycin appears in breast milk. Because of the potential for adverse reactions in nursing infants, breastfeeding while using Neuac Gel is not recommended.

Additional Information

Our Neuac (clindamycin phosphate and benzoyl peroxide) Gel, 1.2%/5% Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Acne is the result of an allergy. See Answer
Neuac Consumer Information

Benzoyl peroxide can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.

Stop using this medicine and get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe redness, burning, stinging, or peeling of treated skin areas; or
  • diarrhea that is watery or bloody.

Common side effects may include:

  • mild burning or stinging;
  • itching or tingly feeling;
  • dryness or peeling of treated skin; or
  • redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Neuac (Clindamycin Phosphate And Benzoyl Peroxide Gel)

SLIDESHOW

Skin Health: 15 Tips for Clear Skin See Slideshow
Neuac Professional Information

SIDE EFFECTS

The following adverse reaction is described in more detail in the Warnings and Precautions section of the label:

  • Colitis [see WARNINGS AND PRECAUTIONS].

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

During clinical trials, 397 subjects used clindamycin phosphate and benzoyl peroxide gel, 1.2%/5% once daily for 11 weeks for the treatment of moderate to moderately severe facial acne vulgaris. All subjects were graded for facial local skin reactions (erythema, peeling, burning, and dryness) on the following scale: 0 = absent, 1 = mild, 2 = moderate, and 3 = severe. The percentage of subjects that had symptoms present before treatment (at baseline) and during treatment is presented in Table 1.

Table 1: Local Skin Reactions With Use Of Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/5% Combined Results From Five Trials (n=397)

Symptom% of Subjects Using Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/5% with Symptom Present
Before Treatment (Baseline)During Treatment
MildModerateSevereMildModerateSevere
Erythema28%3%026%5%0
Peeling6%<1%017%2%0
Burning3%<1%05%<1%0
Dryness6%<1%015%1%0

(Percentages derived by number of subjects receiving clindamycin phosphate and benzoyl peroxide gel, 1.2%/5% with symptom score/number of enrolled subjects receiving clindamycin phosphate and benzoyl peroxide gel, 1.2%/5%).

Postmarketing Experience

The following adverse reactions have been identified during post approval use of clindamycin phosphate and benzoyl peroxide gel, 1.2%/5%. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Anaphylaxis, as well as allergic reactions leading to hospitalization, has been reported in postmarketing use with clindamycin phosphate and benzoyl peroxide gel, 1.2%/5%.

Urticaria, application site reactions, including discoloration have been reported.

Read the entire FDA prescribing information for Neuac (Clindamycin Phosphate And Benzoyl Peroxide Gel)

© Neuac Patient Information is supplied by Cerner Multum, Inc. and Neuac Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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