Medical Editor: John P. Cunha, DO, FACOEP
What Is Neurontin?
Neurontin (gabapentin) is an anti-epileptic medication used to treat seizures. Neurontin is used alone or in combination with other medications to treat seizures caused by epilepsy in adults and children who are at least 12 years old. Neurontin is also used to treat nerve pain caused by shingles (herpes zoster).
What Are Side Effects of Neurontin?
Common side effects of Neurontin include:
- dizziness,
- drowsiness,
- unsteadiness,
- memory loss,
- lack of coordination,
- difficulty speaking,
- viral infections,
- tremors,
- double vision,
- fever,
- unusual eye movements, and
- jerky movements.
Other side effects of Neurontin include mood or behavior changes, depression, or anxiety.
Dosage for Neurontin
In adults with postherpetic neuralgia, Neurontin may be initiated on Day 1 as a single 300 mg dose, on Day 2 as 600 mg/day (300 mg two times a day), and on Day 3 as 900 mg/day (300 mg three times a day). The starting dose of Neurontin for epilepsy with partial onset seizures in patients 12 years of age and above is 300 mg three times a day.
What Drugs, Substances, or Supplements Interact with Neurontin?
Neurontin may interact with hydrocodone, morphine, and naproxen. Tell your doctor all medications and supplements you use.
Neurontin During Pregnancy and Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant while using Neurontin; it is unknown if Neurontin will harm a fetus. Neurontin passes into breast milk and may harm a nursing baby. Breastfeeding while using Neurontin is not recommended.
Additional Information
Our Neurontin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, upper stomach pain, or yellowing of your skin or eyes.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
- weak or shallow breathing;
- blue-colored skin, lips, fingers, and toes;
- confusion, extreme drowsiness or weakness;
- problems with balance or muscle movement;
- unusual or involuntary eye movements; or
- increased seizures.
Gabapentin can cause life-threatening breathing problems. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Breathing problems may be more likely in older adults or in people with COPD.
Some side effects are more likely in children taking gabapentin. Contact your doctor if the child taking this medicine has any of the following side effects:
- changes in behavior;
- memory problems;
- trouble concentrating; or
- acting restless, hostile, or aggressive.
Common side effects may include:
- headache;
- dizziness, drowsiness, tiredness;
- problems with balance or eye movements; or
- (in children) fever, nausea, vomiting.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Neurontin (Gabapentin)

SLIDESHOW
What Is Epilepsy? Symptoms, Causes, and Treatments See SlideshowSIDE EFFECTS
The following serious adverse reactions are discussed in greater detail in other sections:
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multiorgan Hypersensitivity [see WARNINGS AND PRECAUTIONS]
- Anaphylaxis and Angioedema [see WARNINGS AND PRECAUTIONS]
- Somnolence/Sedation and Dizziness [see WARNINGS AND PRECAUTIONS]
- Withdrawal Precipitated Seizure, Status Epilepticus [see WARNINGS AND PRECAUTIONS]
- Suicidal Behavior and Ideation [see WARNINGS AND PRECAUTIONS]
- Neuropsychiatric Adverse Reactions (Pediatric Patients 3 to 12 Years of Age) [see WARNINGS AND PRECAUTIONS]
- Sudden and Unexplained Death in Patients with Epilepsy [see WARNINGS AND PRECAUTIONS]
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Postherpetic Neuralgia
The most common adverse reactions associated with the use of NEURONTIN in adults, not seen at an equivalent frequency among placebo-treated patients, were dizziness, somnolence, and peripheral edema.
In the 2 controlled trials in postherpetic neuralgia, 16% of the 336 patients who received NEURONTIN and 9% of the 227 patients who received placebo discontinued treatment because of an adverse reaction. The adverse reactions that most frequently led to withdrawal in NEURONTIN-treated patients were dizziness, somnolence, and nausea.
Table 3 lists adverse reactions that occurred in at least 1% of NEURONTIN-treated patients with postherpetic neuralgia participating in placebocontrolled trials and that were numerically more frequent in the NEURONTIN group than in the placebo group.
TABLE 3. Adverse Reactions in Pooled Placebo-Controlled Trials in Postherpetic Neuralgia
NEURONTIN N=336 % | Placebo N=227 % | |
Body as a Whole | ||
Asthenia | 6 | 5 |
Infection | 5 | 4 |
Accidental injury | 3 | 1 |
Digestive System | ||
Diarrhea | 6 | 3 |
Dry mouth | 5 | 1 |
Constipation | 4 | 2 |
Nausea | 4 | 3 |
Vomiting | 3 | 2 |
Metabolic and Nutritional Disorders | ||
Peripheral edema | 8 | 2 |
Weight gain | 2 | 0 |
Hyperglycemia | 1 | 0 |
Nervous System | ||
Dizziness | 28 | 8 |
Somnolence | 21 | 5 |
Ataxia | 3 | 0 |
Abnormal thinking | 3 | 0 |
Abnormal gait | 2 | 0 |
Incoordination | 2 | 0 |
Respiratory System | ||
Pharyngitis | 1 | 0 |
Special Senses | ||
Amblyopia* | 3 | 1 |
Conjunctivitis | 1 | 0 |
Diplopia | 1 | 0 |
Otitis media | 1 | 0 |
*Reported as blurred vision |
Other reactions in more than 1% of patients but equally or more frequent in the placebo group included pain, tremor, neuralgia, back pain, dyspepsia, dyspnea, and flu syndrome.
There were no clinically important differences between men and women in the types and incidence of adverse reactions. Because there were few patients whose race was reported as other than white, there are insufficient data to support a statement regarding the distribution of adverse reactions by race.
Epilepsy With Partial Onset Seizures (Adjunctive Therapy)
The most common adverse reactions with NEURONTIN in combination with other antiepileptic drugs in patients >12 years of age, not seen at an equivalent frequency among placebo-treated patients, were somnolence, dizziness, ataxia, fatigue, and nystagmus.
The most common adverse reactions with NEURONTIN in combination with other antiepileptic drugs in pediatric patients 3 to 12 years of age, not seen at an equal frequency among placebo-treated patients, were viral infection, fever, nausea and/or vomiting, somnolence, and hostility [see WARNINGS AND PRECAUTIONS].
Approximately 7% of the 2074 patients >12 years of age and approximately 7% of the 449 pediatric patients 3 to 12 years of age who received NEURONTIN in premarketing clinical trials discontinued treatment because of an adverse reaction. The adverse reactions most commonly associated with withdrawal in patients >12 years of age were somnolence (1.2%), ataxia (0.8%), fatigue (0.6%), nausea and/or vomiting (0.6%), and dizziness (0.6%). The adverse reactions most commonly associated with withdrawal in pediatric patients were emotional lability (1.6%), hostility (1.3%), and hyperkinesia (1.1%).
Table 4 lists adverse reactions that occurred in at least 1% of NEURONTIN-treated patients >12 years of age with epilepsy participating in placebocontrolled trials and were numerically more common in the NEURONTIN group. In these studies, either NEURONTIN or placebo was added to the patient's current antiepileptic drug therapy.
TABLE 4. Adverse Reactions in Pooled Placebo-Controlled Add-On Trials In Epilepsy Patients >12 years of age
NEURONTIN* N=543 % | Placebo* N=378 % | |
Body As A Whole | ||
Fatigue | 11 | 5 |
Increased Weight | 3 | 2 |
Back Pain | 2 | 1 |
Peripheral Edema | 2 | 1 |
Cardiovascular | ||
Vasodilatation | 1 | 0 |
Digestive System | ||
Dyspepsia | 2 | 1 |
Dry Mouth or Throat | 2 | 1 |
Constipation | 2 | 1 |
Dental Abnormalities | 2 | 0 |
Nervous System | ||
Somnolence | 19 | 9 |
Dizziness | 17 | 7 |
Ataxia | 13 | 6 |
Nystagmus | 8 | 4 |
Tremor | 7 | 3 |
Dysarthria | 2 | 1 |
Amnesia | 2 | 0 |
Depression | 2 | 1 |
Abnormal thinking | 2 | 1 |
Abnormal coordination | 1 | 0 |
Respiratory System | ||
Pharyngitis | 3 | 2 |
Coughing | 2 | 1 |
Skin and Appendages | ||
Abrasion | 1 | 0 |
Urogenital System | ||
Impotence | 2 | 1 |
Special Senses | ||
Diplopia | 6 | 2 |
Amblyopia† | 4 | 1 |
* Plus background antiepileptic drug therapy † Amblyopia was often described as blurred vision. |
Among the adverse reactions occurring at an incidence of at least 10% in NEURONTIN-treated patients, somnolence and ataxia appeared to exhibit a positive dose-response relationship.
The overall incidence of adverse reactions and the types of adverse reactions seen were similar among men and women treated with NEURONTIN. The incidence of adverse reactions increased slightly with increasing age in patients treated with either NEURONTIN or placebo. Because only 3% of patients(28/921) in placebo-controlled studies were identified as nonwhite (black or other), there are insufficient data to support a statement regarding the distribution of adverse reactions by race.
Table 5 lists adverse reactions that occurred in at least 2% of NEURONTIN-treated patients, age 3 to 12 years of age with epilepsy participating in placebo-controlled trials, and which were numerically more common in the NEURONTIN group.
TABLE 5. Adverse Reactions in a Placebo-Controlled Add-On Trial in Pediatric Epilepsy Patients Age 3 to 12 Years
NEURONTIN* N=119 % | Placebo* N=128 % | |
Body As A Whole | ||
Viral Infection | 11 | 3 |
Fever | 10 | 3 |
Increased Weight | 3 | 1 |
Fatigue | 3 | 2 |
Digestive System | ||
Nausea and/or Vomiting | 8 | 7 |
Nervous System | ||
Somnolence | 8 | 5 |
Hostility | 8 | 2 |
Emotional Lability | 4 | 2 |
Dizziness | 3 | 2 |
Hyperkinesia | 3 | 1 |
Respiratory System | ||
Bronchitis | 3 | 1 |
Respiratory Infection | 3 | 1 |
*Plus background antiepileptic drug therapy |
Other reactions in more than 2% of pediatric patients 3 to 12 years of age but equally or more frequent in the placebo group included: pharyngitis, upper respiratory infection, headache, rhinitis, convulsions, diarrhea, anorexia, coughing, and otitis media.
Postmarketing Experience
The following adverse reactions have been identified during postmarketing use of NEURONTIN. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Hepatobiliary disorders: jaundice
Investigations: elevated creatine kinase, elevated liver function tests
Metabolism and nutrition disorders: hyponatremia
Musculoskeletal and connective tissue disorder: rhabdomyolysis
Nervous system disorders: movement disorder
Psychiatric disorders: agitation
Reproductive system and breast disorders: breast enlargement, changes in libido, ejaculation disorders and anorgasmia
Skin and subcutaneous tissue disorders: angioedema [see WARNINGS AND PRECAUTIONS], erythema multiforme, Stevens-Johnson syndrome.
Adverse reactions following the abrupt discontinuation of gabapentin have also been reported. The most frequently reported reactions were anxiety, insomnia, nausea, pain, and sweating.
Read the entire FDA prescribing information for Neurontin (Gabapentin)

QUESTION
If you have had a seizure, it means you have epilepsy. See AnswerRead the Neurontin User Reviews »
© Neurontin Patient Information is supplied by Cerner Multum, Inc. and Neurontin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
