Nitro-Dur Side Effects Center

Last updated on RxList: 8/1/2022
Nitro-Dur Side Effects Center

What Is Nitro-Dur?

Nitro-Dur (nitroglycerin) transdermal is a nitrate used to prevent attacks of chest pain (angina). Nitro-Dur is available in generic form.

What Are Side Effects of Nitro-Dur?

Common side effects of Nitro-Dur include:

  • headache
  • dizziness
  • weakness
  • nervousness
  • lightheadedness
  • nausea
  • vomiting
  • upset stomach
  • flushing (warmth, redness, or tingly feeling under your skin)
  • skin rash or itching as your body adjusts to this medication

What are the possible side effects of Nitro-Dur?

Nitro-Dur may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • worsening chest pain,
  • pounding heartbeats or fluttering in your chest,
  • slow heart rate,
  • lightheadedness,
  • chest pain or pressure,
  • pain spreading to your jaw or shoulder,
  • nausea, and
  • sweating

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Nitro-Dur

The suggested starting dose of Nitro-Dur is between 0.2 mg/hr and 0.4 mg/hr.

What Drugs, Substances, or Supplements Interact with Nitro-Dur?

Nitro-Dur may interact with blood pressure medications, diuretics (water pills), cold or allergy medicines, diet pills, over-the-counter pain medicine, erectile dysfunction medication, migraine headache medication, beta-blockers, or calcium channel blockers. Tell your doctor all prescription and over-the-counter medications you use.

Nitro-Dur During Pregnancy or Breastfeeding

During pregnancy, Nitro-Dur should be used only when prescribed. It is unknown if this drug passes into breast milk or if it may harm a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Nitro-Dur (nitroglycerin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Nitro-Dur Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening chest pain;
  • pounding heartbeats or fluttering in your chest;
  • slow heart rate;
  • a light-headed feeling, like you might pass out; or
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Serious side effects may be more likely in older adults.

Nitroglycerin can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop using this medicine. Ask your doctor before using any headache pain medication.

Common side effects may include:

  • headache; or
  • feeling light-headed.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Nitro-Dur (Nitroglycerin)


See Images
Nitro-Dur Professional Information


The vasodilating effects of nitroglycerin may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.

Concomitant use of NITRO-DUR with phosphodiesterase inhibitors in any form is contraindicated (see CONTRAINDICATIONS).

Concomitant use of NITRO-DUR with riociguat, a soluble guanylate cyclase stimulator, is contraindicated (see CONTRAINDICATIONS).


Adverse reactions to nitroglycerin are generally dose related, and almost all of these reactions are the result of nitroglycerins activity as a vasodilator. Headache, which may be severe, is the most commonly reported side effect. Headache may be recurrent with each daily dose, especially at higher doses. Transient episodes of lightheadedness, occasionally related to blood pressure changes, may also occur. Hypotension occurs infrequently, but in some patients it may be severe enough to warrant discontinuation of therapy. Syncope, crescendo angina, and rebound hypertension have been reported but are uncommon.

Allergic reactions to nitroglycerin are also uncommon, and the great majority of those reported have been cases of contact dermatitis or fixed drug eruptions in patients receiving nitroglycerin in ointments or patches. There have been a few reports of genuine anaphylactoid reactions, and these reactions can probably occur in patients receiving nitroglycerin by any route.

Extremely rarely, ordinary doses of organic nitrates have caused methemoglobinemia in normal-seeming patients. Methemoglobinemia is so infrequent at these doses that further discussion of its diagnosis and treatment is deferred (see OVERDOSE).

Application-site irritation may occur but is rarely severe.

In two placebo-controlled trials of intermittent therapy with nitroglycerin patches at 0.2 to 0.8 mg/hr, the most frequent adverse reactions among 307 subjects were as follows:

Placebo Patch
Headache 18% 63%
Lightheadedness 4% 6%
Hypotension, and/or Syncope 0% 4%
Increased Angina 2% 2%

To report SUSPECTED ADVERSE REACTIONS, contact USPharma LLC at 1(844)-750-3729 or FDA at 1-800-FDA- 1088 or

Read the entire FDA prescribing information for Nitro-Dur (Nitroglycerin)


Heart Disease: Symptoms, Signs, and Causes See Slideshow

© Nitro-Dur Patient Information is supplied by Cerner Multum, Inc. and Nitro-Dur Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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