Reviewed on 9/15/2022

What Is Nizatidine and How Does It Work?

Nizatidine is a prescription medication used to treat ulcers in the stomach and intestines. It also treats heartburn and erosive esophagitis caused by gastroesophageal reflux disease (GERD), a condition in which acid backs up from the stomach into the esophagus

What Are Side Effects Associated with Using Nizatidine?

Common side effects of Nizatidine include:

  • headache, dizziness.
  • diarrhea; or
  • runny or stuffy nose.

Serious side effects of Nizatidine include:

  • hives. 
  • difficulty breathing. 
  • swelling of the face, lips, tongue, or throat.
  • worsening heartburn.
  • chest pain.
  • pale skin, feeling light-headed or short of breath; or
  • jaundice (yellowing of the skin or eyes).

Rare side effects of Nizatidine include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Are Dosages of Nizatidine?

Adult and pediatric dosage


  • 150 mg
  • 300 mg

Oral solution

  • 15 mg/mL


  • 75 mg

Gastroesophageal reflux disease

Adult dosage

  • Oral: 150 mg twice daily; duration of therapy depends on symptoms.

Pediatric dosage

Children below 11 years: 

  • Limited data available: 5 mg/kg/dose twice daily; maximum daily dose: 300 mg/day 

Children above 12 years: 

  • 150 mg twice daily; maximum daily dose: 300 mg/day


Pediatric dosage

Infants above 6 months and Children below 11 years: 

  • Limited data available: 5 mg/kg/dose twice daily. 

Children above 12 years: 

  • 150 mg twice daily; maximum daily dose: 300 mg/day

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Other Drugs Interact with Nizatidine?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Nizatidine?


  • Hypersensitivity to nizatidine or other H2 receptor antagonists
  • Children younger than 12 years old

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Nizatidine?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Nizatidine?”


  • Allow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
  • Adjust dosage in renal impairment; patients with kidney disease should ask their doctor before use
  • If a patient taking a prescription drug, the patient should ask a doctor or a pharmacist whether acid reducers can be taken concomitantly with it
  • Prolonged therapy may lead to vitamin B12 malabsorption and subsequently, deficiency
  • Relief of symptoms does not preclude the absence of malignancy
  • Increased risk for development of acute gastroenteritis and community-acquired pneumonia associated reported in pediatric patients
  • May see false positive urobilinogen secondary to nizatidine
  • To help manage your heartburn symptoms, avoid certain things that can make heartburn worse, such as:
  • lying down or bending over shortly after eating;
  • eating late at night;
  • overeating or eating quickly;
  • being overweight;
  • wearing clothing that is tight around your waist;
  • smoking;
  • drinking alcohol; or
  • eating spicy foods, fried foods, chocolate, caffeine, or acidic fruits or vegetables.

Pregnancy and Lactation

  • It is not known whether nizatidine will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.
  • Lactation
    • Nizatidine can pass into breast milk and may harm a nursing baby. You should not breast-feed while taking this medication.

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