Norgesic Side Effects Center

Last updated on RxList: 5/6/2021
Norgesic Side Effects Center

What Is Norgesic?

Norgesic (orphenadrine citrate, aspirin and caffeine) is a combination of a muscle relaxant, a pain reliever, and caffeine which increases the pain relieving effects of the other drugs, used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Norgesic is available in generic form.

What Are Side Effects of Norgesic?

Common side effects of Norgesic include dizziness, drowsiness, lightheadedness, blurred vision or large pupils, weakness, headache, stomach upset, heartburn, nausea, vomiting, constipation, dry mouth, tremor, difficulty urinating or increased urination, hiccups, trouble sleeping, or ringing in the ears.

Dosage for Norgesic

The adult dose of Norgesic is 1 to 2 tablets, 3 to 4 times daily. The adult dose of Norgesic Forte is ½ to 1 tablet 3 to 4 times daily.

What Drugs, Substances, or Supplements Interact with Norgesic?

Norgesic may interact with antidepressants, alcohol, antihistamines, sedatives, other pain relievers, anxiety medicines, muscle relaxants, anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), or other salicylates. Tell your doctor all medications you use.

Norgesic During Pregnancy and Breastfeeding

During pregnancy, Norgesic should be used only when prescribed. Aspirin is not recommended for use during pregnancy. This medication passes into breast milk and may harm a nursing infant. Breastfeeding while using this drug is not recommended.

Additional Information

Our Norgesic (orphenadrine citrate, aspirin and caffeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Norgesic Professional Information


Side effects of Norgesic and Norgesic Forte Tablets are those seen with aspirin and caffeine or those usually associated with mild anticholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of Orphenadrine Citrate, Aspirin, and Caffeine Tablets has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Norgesic and Norgesic Forte Tablets. Some patients may experience transient episodes of lightheadedness, dizziness or syncope.


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Read the entire FDA prescribing information for Norgesic (Orphenadrine Citrate with Aspirin and Caffeine)


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© Norgesic Patient Information is supplied by Cerner Multum, Inc. and Norgesic Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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