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Last reviewed on RxList: 4/7/2009
Norgesic Side Effects Center

Last reviewed on RxList 11/5/2015

Norgesic (orphenadrine citrate, aspirin and caffeine) is a combination of a muscle relaxant, a pain reliever, and caffeine which increases the pain relieving effects of the other drugs, used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Norgesic is available in generic form. Common side effects of Norgesic include dizziness, drowsiness, lightheadedness, blurred vision or large pupils, weakness, headache, stomach upset, heartburn, nausea, vomiting, constipation, dry mouth, tremor, difficulty urinating or increased urination, hiccups, trouble sleeping, or ringing in the ears.

The adult dose of Norgesic is 1 to 2 tablets, 3 to 4 times daily. The adult dose of Norgesic Forte is � to 1 tablet 3 to 4 times daily. Norgesic may interact with antidepressants, alcohol, antihistamines, sedatives, other pain relievers, anxiety medicines, muscle relaxants, anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), or other salicylates. Tell your doctor all medications you use. During pregnancy, Norgesic should be used only when prescribed. Aspirin is not recommended for use during pregnancy. This medication passes into breast milk and may harm a nursing infant. Breastfeeding while using this drug is not recommended.

Our Norgesic (orphenadrine citrate, aspirin and caffeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Norgesic Consumer Information

If you experience any of the following serious side effects, stop taking aspirin/caffeine/orphenadrine and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • an irregular or a very fast heartbeat;
  • confusion, hallucinations, or abnormal behavior;
  • red, black, or bloody stools; or
  • blood in vomit.

Other, less serious side effects may be more likely to occur. Continue to take aspirin/caffeine/orphenadrine and talk to your doctor if you experience

  • drowsiness or dizziness;
  • headache;
  • tremor;
  • blurred vision or large pupils;
  • difficulty urinating;
  • hiccups;
  • faint ringing in the ears; or
  • nausea, vomiting, or constipation.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Norgesic (Orphenadrine Citrate with Aspirin and Caffeine)

Norgesic Professional Information


Side effects of Norgesic (orphenadrine citrate with aspirin and caffeine) or Norgesic (orphenadrine citrate with aspirin and caffeine) Forte are those seen with aspirin and caffeine or those usually associated with mild anticholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilatation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of Norgesic (orphenadrine citrate with aspirin and caffeine) has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Norgesic (orphenadrine citrate with aspirin and caffeine) or Norgesic (orphenadrine citrate with aspirin and caffeine) Forte. Some patients may experience transient episodes of light-headedness, dizziness or syncope.

Read the entire FDA prescribing information for Norgesic (Orphenadrine Citrate with Aspirin and Caffeine)

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© Norgesic Patient Information is supplied by Cerner Multum, Inc. and Norgesic Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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