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Normal Saline

Last reviewed on RxList: 8/12/2020
Normal Saline Side Effects Center

What Is Normal Saline?

Normal Saline (sodium chloride) Injection is a fluid and electrolyte replenisher used as a source of water and electrolytes. Normal Saline is available in generic form.

What Are Side Effects of Normal Saline?

Common side effects of Normal Saline include:

  • fever,
  • injection site swelling,
  • redness, or
  • infection.

Contact your doctor if you experience serious side effects of Normal Saline including:

  • fast heartbeat,
  • fever,
  • rash,
  • joint pain, or
  • shortness of breath.

Dosage for Normal Saline

Dosage of Normal Saline is dependent upon the age, weight and clinical condition of the patient as well as laboratory determinations.

What Drugs, Substances, or Supplements Interact with Normal Saline?

Normal Saline may interact with corticosteroids or corticotropin. Tell your doctor all medications and supplements you use.

Normal Saline During Pregnancy and Breastfeeding

During pregnancy, Normal Saline should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Normal Saline (sodium chloride) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Normal Saline Professional Information


Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

Read the entire FDA prescribing information for Normal Saline (Sodium Chloride Injection)


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© Normal Saline Patient Information is supplied by Cerner Multum, Inc. and Normal Saline Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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