Nourianz vs. Rytary

Reviewed on 9/17/2019

Are Nourianz and Rytary the Same Thing?

Nourianz (istradefylline) and Rytary (carbidopa and levodopa) are used to treat different aspects of Parkinson's disease.

Nourianz is indicated as adjunctive treatment to levodopa/carbidopa in adult patients with Parkinson's disease experiencing "off" episodes.

Rytary is used to treat Parkinson's disease, post-encephalitic Parkinsonism, and Parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.

Nourianz and Rytary belong to different drug classes. Nourianz is an adenosine receptor antagonist and Rytary is a combination of an inhibitor of aromatic amino acid decarboxylation and an aromatic amino acid.

Side effects of Nourianz and Rytary that are similar include involuntary muscle movements, dizziness, constipation, nausea, and sleep problems (insomnia).

Side effects of Nourianz that are different from Rytary include hallucinations.

Side effects of Rytary that are different from Nourianz include headache, abnormal dreams, dry mouth, anxiety, vomiting, and low blood pressure and dizziness upon standing.

Nourianz may interact with itraconazole, ketoconazole, clarithromycin, rifampin, St. John's wort, midazolam, atorvastatin, seizure medications, and digoxin.

Rytary may interact with MAO inhibitors, phenothiazines, butyrophenones, risperidone, metoclopramide, isoniazid, iron salts, or multi-vitamins containing iron salts.

What Are Possible Side Effects of Nourianz?

Common side effects of Nourianz include:

  • involuntary muscle movements,
  • dizziness,
  • constipation,
  • nausea,
  • hallucinations, and
  • insomnia

What Are Possible Side Effects of Rytary?

Common side effects of Rytary include:

What Is Nourianz?

Nourianz (istradefylline) is an adenosine receptor antagonist indicated as adjunctive treatment to levodopa/carbidopa in adult patients with Parkinson's disease (PD) experiencing "off" episodes.

What Is Rytary?

Rytary (carbidopa and levodopa) is a combination an inhibitor of aromatic amino acid decarboxylation and an aromatic amino acid, used for the treatment of Parkinson's disease, post-encephalitic Parkinsonism, and Parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.

QUESTION

Parkinson's disease is only seen in people of advanced age. See Answer

What Drugs Interact With Nourianz?

Nourianz may interact with itraconazole, ketoconazole, clarithromycin, carbamazepine, rifampin, phenytoin, St. John's wort, midazolam, atorvastatin, and digoxin. Nourianz is not recommended for use during pregnancy; it may harm a fetus. Women of childbearing potential are advised to use contraception during treatment with Nourianz. It is unknown if Nourianz passes into breast milk or how it would affect a nursing infant. Consult your doctor before breastfeeding.

What Drugs Interact With Rytary?

Rytary may interact with MAO inhibitors, phenothiazines, butyrophenones, risperidone, metoclopramide, isoniazid, iron salts, or multi-vitamins containing iron salts. Tell your doctor all medications and supplements you use. During pregnancy, Rytary should be used only if prescribed. These drugs may pass into breast milk. Consult your doctor before breastfeeding.

How Should Nourianz Be Taken?

The recommended dosage of Nourianz is 20 mg orally once daily. The dosage may be increased to a maximum of 40 mg once daily.

How Should Rytary Be Taken?

The recommended starting dosage of Rytary is 23.75 mg/95 mg taken orally three times a day for the first 3 days. On the fourth day of treatment, the dosage of Rytary may be increased to 36.25 mg/145 mg taken three times a day.

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References
Kyowa Kirin Co. Nourianz Drug Information.

https://www.nourianz.com/

Impax Laboratories, Inc. Rytary Product Information.

https://rytary.com/

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