Novolog Mix 50-50

Last updated on RxList: 11/22/2016
Novolog Mix 50-50 Side Effects Center

Last reviewed on RxList 5/20/2016

NovoLog Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) is a form of insulin used as an adjunct to diet and exercise to improve glycemic control in patients with diabetes mellitus. The brand name NovoLog Mix 50/50 is discontinued, but generic versions may be available. Common side effects of NovoLog Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) include:

  • allergic reactions
  • injection site reactions
  • fat loss, and
  • itching or rash

Dose regimens of NovoLog Mix 50/50 will vary among patients and should be determined by the physician familiar with the patient's lifestyle variables. NovoLog Mix 50/50 may interact with oral antidiabetic products, other insulin products, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase (MAO) inhibitors, propoxyphene, salicylates, somatostatin analog, antibiotics, corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazines, somatropin, thyroid hormones, estrogens, oral contraceptives, beta-blockers, clonidine, lithium, alcohol, pentamidine, clonidine, guanethidine, and reserpine. Tell your doctor all medications and supplements you use. During pregnancy, NovoLog Mix 50/50 should be used only if prescribed. Talk to your doctor about your insulin needs during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our NovoLog Mix 50/50 (50% insulin aspart protamine suspension and 50% insulin aspart injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Diabetes: What Raises and Lowers Your Blood Sugar Level? See Slideshow
Novolog Mix 50-50 Professional Information


During clinical trials the overall adverse event profile of NovoLog® Mix 50/50 was comparable to Novolin® 70/30.

Adverse events commonly associated with human insulin therapy include the following:

Body as whole: allergic reactions (see PRECAUTIONS, Allergy).

Skin and Appendages: Injection site reaction, lipodystrophy, pruritus, rash (see PRECAUTIONS, Allergy).

Hypoglycemia: see WARNINGS and PRECAUTIONS.

Read the entire FDA prescribing information for Novolog Mix 50-50 (50% Insulin Aspart Protamine Suspension and 50% Insulin Aspart Injection)


Diabetes is defined best as... See Answer

© Novolog Mix 50-50 Patient Information is supplied by Cerner Multum, Inc. and Novolog Mix 50-50 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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