Medical Editor: John P. Cunha, DO, FACOEP
What Is Noxipak?
Noxipak (fluocinolone acetonide and urea kit) is a combination of a corticosteroid and a keratolytic used to manage hypertrophic tissues, keloid tissues, dermatitis, and dermatoses.
What Are Side Effects of Noxipak?
Common side effects of Noxipak include:
- burning,
- itching,
- irritation,
- dryness,
- hair bumps,
- abnormal hair growth
- acne,
- loss of pigmentation,
- sores around the mouth,
- allergic contact dermatitis,
- softening and breakdown of the skin,
- secondary infection,
- skin atrophy,
- stretch marks, and
- sweat rash
Dosage for Noxipak
First apply fluocinolone acetonide 0.01% topical solution to the affected area, rub into skin until absorbed. Then apply urea 20% cream and rub into skin until completely absorbed. Apply twice a day or as directed by your physician. Cover the affected area with silicone tape at bedtime or as directed by your physician.
Noxipak In Children
Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than mature patients because of a larger skin surface area to body weight ratio.
Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.
Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of children.
What Drugs, Substances, or Supplements Interact with Noxipak?
Noxipak may interact with other medicines.
Tell your doctor all medications and supplements you use.
Noxipak During Pregnancy and Breastfeeding
Our Noxipak (fluocinolone acetonide and urea kit) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Additional Information
Our Noxipak 101 Gas (nitric oxide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW
Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases See SlideshowSIDE EFFECTS
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
Burning | Perioral dermatitis |
Itching | Allergic contact dermatitis |
Irritation | Maceration of the skin |
Dryness | Secondary infection |
Folliculitis | Skin atrophy |
Hypertrichosis | Striae |
Acneiform eruptions | Miliaria |
Hypopigmentation |
Read the entire FDA prescribing information for Noxipak (Fluocinolone Acetonide Topical Solution)

QUESTION
Ringworm is caused by a fungus. See Answer© Noxipak Patient Information is supplied by Cerner Multum, Inc. and Noxipak Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.