Nubeqa vs. Erleada

Reviewed on 11/30/2020

Are Nubeqa and Erleada the Same Thing?

Nubeqa (darolutamide) and Erleada (apalutamide tablets) are androgen receptor inhibitors indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

Side effects of Nubeqa and Erleada that are similar include fatigue, pain/swelling in extremities, and rash.

Side effects of Erleada that are different from Nubeqa include high blood pressure (hypertension), rash, diarrhea, nausea, weight loss, joint pain, falls, hot flushes, decreased appetite, and fractures.

Nubeqa may interact with rifampicin, itraconazole, midazolam, and rosuvastatin.

Erleada may interact with medications that are sensitive substrates of CYP3A4, CYP2C19, CYP2C9, UGT, P-gp, BCRP, or OATP1B1.

What Are Possible Side Effects of Nubeqa?

Common side effects of Nubeqa include:

  • fatigue,
  • pain in extremities, and
  • rash

What Are Possible Side Effects of Erleada?

Common side effects of Erleada include:

  • fatigue,
  • high blood pressure (hypertension),
  • rash,
  • diarrhea,
  • nausea,
  • weight loss,
  • joint pain,
  • falls,
  • hot flushes,
  • decreased appetite,
  • fractures, and
  • swelling of extremities

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What Is Nubeqa?

Nubeqa (darolutamide) is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

What Is Erleada?

Erleada (apalutamide tablets) is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

What Drugs Interact With Nubeqa?

Nubeqa may interact with rifampicin, itraconazole, midazolam, and rosuvastatin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Erleada?

Erleada can be taken with or without food. Erleada may interact with medications that are sensitive substrates of CYP3A4, CYP2C19, CYP2C9, UGT, P-gp, BCRP, or OATP1B1. Tell your doctor all medications and supplements you use.

How Should Nubeqa be Taken?

The dose of Nubeqa is 600 mg, (two 300 mg tablets) administered orally twice daily with food. Patients should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy.

How Should Erleada be Taken?

The dose of Erleada is 240 mg (four 60 mg tablets) administered orally once daily. Swallow tablets whole.

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References
Bayer Pharmaceuticals. Nubeqa Product Information

https://www.nubeqahcp.com/

Janssen. Erleada Product Information.

https://www.erleadahcp.com/

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