Nubeqa vs. Xtandi

Reviewed on 11/30/2020

Are Nubeqa and Xtandi the Same Thing?

Nubeqa (darolutamide) and Xtandi (enzalutamide) are androgen receptor inhibitors indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

Xtandi is used in patients who have previously received Docefrez (docetaxel).

Side effects of Nubeqa and that are similar include fatigue/tiredness.

Side effects of Nubeqa that are different from Xtandi include pain in extremities and rash.

Side effects of Xtandi that are different from Nubeqa include seizures, back pain, diarrhea, joint or muscle pain, hot flashes, flushing (warmth, redness, or hot feeling), headache, muscle weakness or stiffness, anxiety, dizziness, sleep problems (insomnia), numbness/burning pain/tingling/prickly feeling under your skin, swelling in your hands or feet, cold symptoms (such as stuffy nose, sneezing, and sore throat), high blood pressure (hypertension), upper respiratory tract infection, blood in the urine, urinary frequency, dry skin, itching, and nosebleeds.

Nubeqa may interact with rifampicin, itraconazole, midazolam, and rosuvastatin.

Xtandi may interact with other drugs.

What Are Possible Side Effects of Nubeqa?

Common side effects of Nubeqa include:

  • fatigue,
  • pain in extremities, and
  • rash

What Are Possible Side Effects of Xtandi?

Common side effects of Xtandi include:

  • seizures,
  • back pain,
  • diarrhea,
  • joint or muscle pain,
  • hot flashes,
  • flushing (warmth, redness, or hot feeling),
  • headache,
  • muscle weakness or stiffness,
  • anxiety,
  • dizziness,
  • sleep problems (insomnia),
  • feeling tired,
  • numbness/burning pain/tingling/prickly feeling under your skin,
  • swelling in your hands or feet,
  • cold symptoms (such as stuffy nose, sneezing, and sore throat),
  • high blood pressure,
  • upper respiratory tract infection,
  • blood in the urine,
  • urinary frequency,
  • dry skin,
  • itching, or
  • nosebleeds.

SLIDESHOW

Screening Tests Every Man Should Have See Slideshow

What Is Nubeqa?

Nubeqa (darolutamide) is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

What Is Xtandi?

Xtandi (enzalutamide) is an androgen receptor inhibitor indicated for the treatment of prostate cancer in patients who have previously received Docefrez (docetaxel).

What Drugs Interact With Nubeqa?

Nubeqa may interact with rifampicin, itraconazole, midazolam, and rosuvastatin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Xtandi?

Xtandi may interact with other drugs. Tell your doctor all prescription and OTC medications you are taking.

How Should Nubeqa be Taken?

The dose of Nubeqa is 600 mg, (two 300 mg tablets) administered orally twice daily with food. Patients should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy.

How Should Xtandi be Taken?

Xtandi is available in capsules of 40 mg. The recommended dosage of Xtandi is 160 mg (four 40 mg capsules) administered orally once daily. Swallow capsules whole. Xtandi can be taken with or without food.

IMAGES

See Images
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Bayer Pharmaceuticals. Nubeqa Product Information

https://www.nubeqahcp.com/

Astellas Pharma US, Inc. and Pfizer Inc. Xtandi Product Information.

https://www.xtandi.com/

Health Solutions From Our Sponsors