NuLytely

Last updated on RxList: 6/15/2021
NuLytely Side Effects Center

What Is NuLytely?

NuLytely (polyethylene glycol 3350, sodium chloride, sodium bicarbonate and potassium chloride) for Oral Solution is a combination a laxative and electrolytes used for bowel cleansing prior to colonoscopy and barium enema X-ray examination in adults. NuLytely is available in generic form.

What Are Side Effects of NuLytely?

Common side effects of NuLytely include:

  • nausea
  • abdominal or stomach fullness
  • bloating
  • abdominal cramps
  • vomiting
  • anal/rectal irritation, and
  • rarely, allergic reactions (hives, runny nose, skin rash and itching)

Dosage for NuLytely

The dose of NuLytely for adults is given at a rate of 240 mL (8 oz.) every 10 minutes, until the rectal effluent is clear or 4 liters are consumed.

What Drugs, Substances, or Supplements Interact with NuLytely?

NuLytely may interact with laxatives, and may affect the absorption of other drugs. Tell your doctor all medications and supplements you use.

NuLytely During Pregnancy or Breastfeeding

During pregnancy, NuLytely should be taken only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our NuLytely (polyethylene glycol 3350, sodium chloride, sodium bicarbonate and potassium chloride) for Oral Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

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NuLytely Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • no bowel movement within 2 hours after use;
  • vomiting;
  • dizziness, feeling like you might pass out;
  • little or no urination;
  • a seizure; or
  • signs of an electrolyte imbalance--increased thirst or urination, dry mouth, confusion, constipation, muscle pain or weakness, leg cramps, irregular heartbeats, tingly feeling.

You may need to drink the liquid more slowly, or stop using it for a short time if you have certain side effects. Call your doctor for instructions if you have:

  • gagging, choking, severe stomach pain or bloating;
  • nausea, vomiting, headache, trouble drinking liquids, little or no urinating; or
  • fever, sudden or severe stomach pain, severe diarrhea, rectal bleeding or bright red bowel movements.

Common side effects may include:

  • vomiting, stomach pain, indigestion, bloating;
  • rectal pain or irritation;
  • hunger, thirst, mild nausea;
  • trouble sleeping; or
  • dizziness, chills.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for NuLytely (Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride for Oral Solution)

QUESTION

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NuLytely Professional Information

SIDE EFFECTS

The following serious or otherwise important adverse reactions are described elsewhere in the labeling:

  • Serious Fluid and Serum Chemistry Abnormalities [see WARNINGS AND PRECAUTIONS].
  • Cardiac Arrhythmias [see WARNINGS AND PRECAUTIONS].
  • Seizures [see WARNINGS AND PRECAUTIONS].
  • Renal Impairment [see WARNINGS AND PRECAUTIONS]
  • Colonic Mucosal Ulcerations, Ischemic Colitis and Ulcerative Colitis [see WARNINGS AND PRECAUTIONS]
  • Patients with Significant Gastrointestinal Disease [see WARNINGS AND PRECAUTIONS]
  • Aspiration [see WARNINGS AND PRECAUTIONS]
  • Direct Ingestion [see WARNINGS AND PRECAUTIONS].

The following adverse reactions have been identified during post-approval use of NuLYTELY. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Nausea, abdominal fullness and bloating are the most common adverse reactions (occurred in up to 50% of patients) to administration of NuLYTELY. Abdominal cramps, vomiting and anal irritation occur less frequently. These adverse reactions are transient and usually subside rapidly. Isolated cases of urticaria, rhinorrhea, dermatitis and (rarely) anaphylactic reaction have been reported which may rep-resent allergic reactions.

Published literature contains isolated reports of serious adverse reactions following the administration of PEG-electrolyte solution products in patients over 60 years of age. These adverse events include upper GI bleeding from Mallory-Weiss Tear, esophageal perforation, asystole, sudden dyspnea with pulmonary edema, and “butterfly-like” infiltrates on chest X-ray after vomiting and aspirating PEG.

DRUG INTERACTIONS

Drugs That May Lead To Fluid And Electrolyte Abnormalities

Use caution when prescribing NuLYTELY for patients who are using medications that increase the risk for fluid and electrolyte disturbances or may increase the risk of adverse events of seizure, arrhythmias, and prolonged QT in the setting of fluid and electrolyte abnormalities. Consider additional patient evaluations as appropriate [see WARNINGS AND PRECAUTIONS] in patients taking these concomitant medications.

Potential For Altered Drug Absorption

Oral medication administered within one hour of the start of administration of NuLYTELY may be flushed from the gastrointestinal tract and the medication may not be absorbed properly.

Stimulant Laxatives

Concurrent use of stimulant laxatives and NuLYTELY may increase the risk of mucosal ulceration or ischemic colitis. Avoid use of stimulant laxatives (e.g., bisacodyl, sodium picosulfate) while taking NuLYTELY.

Read the entire FDA prescribing information for NuLytely (Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride for Oral Solution)

© NuLytely Patient Information is supplied by Cerner Multum, Inc. and NuLytely Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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