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NuvaRing

Last reviewed on RxList: 5/28/2020
NuvaRing Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is NuvaRing?

NuvaRing (etonogestrel and ethinyl estradiol vaginal ring) contains a combination of female hormones in a flexible contraceptive vaginal ring used to prevent pregnancy.

What Are Side Effects of NuvaRing?

Common side effects of Nuvaring include:

  • vaginal infections and irritation,
  • vaginal itching or discharge,
  • headache,
  • nausea,
  • vomiting,
  • bloating,
  • stomach cramps,
  • changes in weight or appetite,
  • breast pain/tenderness/swelling,
  • headache,
  • nervousness,
  • dizziness,
  • tired feeling,
  • freckles or darkening of facial skin,
  • increased hair growth,
  • loss of scalp hair,
  • problems with contact lenses,
  • vaginal itching or discharge,
  • changes in your menstrual periods, and
  • decreased sex drive

Dosage for NuvaRing

Nuvaring is inserted once a month for 3 weeks and then removed. A new ring is inserted after a 7 day break.

What Drugs, Substances, or Supplements Interact with NuvaRing?

NuvaRing may interact with bosentan, antibiotics, antifungal medications, drugs to treat hepatitis C or HIV/AIDS, phenobarbital and other barbiturates, St. John's wort, seizure medications, acetaminophen, ascorbic acid (vitamin C), atorvastatin, dantrolene, vaginal miconazole, tizanidine, or tranexamic acid. Tell your doctor all medications and supplements you use.

NuvaRing During Pregnancy and Breastfeeding

Do not use NuvaRing if you are pregnant. NuvaRing can cause birth defects. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before using NuvaRing. The hormones in NuvaRing can pass into breast milk and may harm a nursing baby. NuvaRing may also slow breast milk production. Breastfeeding while using NuvaRing is not recommended.

Additional Information

Our Nuvaring Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Choosing Your Birth Control Method See Slideshow
NuvaRing Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • toxic shock syndrome--sudden fever, body aches, skin rash, vomiting, diarrhea, and feeling dizzy or light-headed;
  • symptoms of depression--mood changes, thoughts about hurting yourself; or
  • liver problems--loss of appetite, upper stomach pain, tiredness, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • headache, mood changes, decreased sex drive;
  • vaginal irritation or discharge, pain in your cervix;
  • menstrual cramps, breast pain or tenderness;
  • nausea, vomiting, stomach pain;
  • acne or weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for NuvaRing (Etonogestrel, Ethinyl Estradiol Vaginal Ring)

QUESTION

Which of the following are methods for contraception? See Answer
NuvaRing Professional Information

SIDE EFFECTS

The following serious adverse reactions with the use of CHCs are discussed elsewhere in the labeling.

Adverse reactions commonly reported by CHC users are:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Trials with a duration of 6 to 13 28-day cycles provided safety data. In total, 2,501 women, aged 18 to 41 contributed 24,520 cycles of exposure.

Common Adverse Reactions (≥ 2%): vaginitis (13.8%), headache (including migraine) (11.2%), mood changes (e.g., depression, mood swings, mood altered, depressed mood, affect lability) (6.4%), device-related events (e.g., expulsion/discomfort/foreign body sensation) (6.3%), nausea/vomiting (5.9%), vaginal discharge (5.7%), increased weight (4.9%), vaginal discomfort (4.0%), breast pain/discomfort/tenderness (3.8%), dysmenorrhea (3.5%), abdominal pain (3.2%), acne (2.4%), and decreased libido (2.0%).

Adverse Reactions (≥ 1%) Leading to Study Discontinuation: 13.0% of the women discontinued from the clinical trials due to an adverse reaction; the most common adverse reactions leading to discontinuation were device-related events (2.7%), mood changes (1.7%), headache (including migraine) (1.5%) and vaginal symptoms (1.2%).

Serious Adverse Reactions: deep vein thrombosis [see WARNINGS AND PRECAUTIONS], anxiety, cholelithiasis, and vomiting.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of NuvaRing. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Immune system disorders: hypersensitivity

Nervous system disorders: stroke/cerebrovascular accident

Vascular disorders: arterial events (including arterial thromboembolism and myocardial infarction), aggravation of varicose veins

Skin and subcutaneous tissue disorders: urticaria, chloasma

Reproductive system and breast disorders: penile disorders, including local reactions on penis (in male partners of women using NuvaRing), galactorrhea

Read the entire FDA prescribing information for NuvaRing (Etonogestrel, Ethinyl Estradiol Vaginal Ring)

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