Nymalize Side Effects Center

Last updated on RxList: 2/10/2021
Nymalize Side Effects Center

What Is Nymalize?

Nymalize (nimodipine) is a calcium channel blocker used to treat patients experiencing symptoms resulting from ruptured blood vessels in the brain (subarachnoid hemorrhage, SAH).

What Are Side Effects of Nymalize?

Common side effects of Nymalize include:

  • decreased blood pressure
  • headache
  • nausea
  • slowed heart rate
  • swelling (edema)
  • diarrhea
  • rash
  • indigestion
  • fast heart rate
  • muscle pain or cramps
  • acne, or
  • depression

Dosage for Nymalize

Nymalize oral solution is available in dosages of 60mg/20mL and should be administered by way of oral, nasogastric tube, or gastric tube route only. Therapy with Nymalize should begin within 96 hours of subarachnoid hemorrhage.

What Drugs, Substances, or Supplements Interact with Nymalize?

Nymalize may interact with high blood pressure medications, St. John's Wort, anticonvulsants, and antibiotics. Tell your doctor all medications you use.

Nymalize During Pregnancy and Breastfeeding

Nymalize may cause fetal harm and should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Nymalize is passes into human milk. Because many drugs are excreted in human milk and because of the potential for serious side effects in babies who breastfeed, consult your doctor before breastfeeding.

Additional Information

Nymalize (nimodipine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Stroke Causes, Symptoms, and Recovery See Slideshow
Nymalize Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • fast or slow heart rate; or
  • swelling in your ankles or feet.

Common side effects may include:

  • low blood pressure (feeling light-headed);
  • nausea, upset stomach;
  • slow heartbeats; or
  • muscle pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Nymalize (Nimodipine Oral Solution)

QUESTION

What is a stroke? See Answer
Nymalize Professional Information

SIDE EFFECTS

The safety and efficacy of NYMALIZE (nimodipine oral solution) in the treatment of patients with SAH is based on adequate and well-controlled studies of nimodipine oral capsules in patients with SAH. NYMALIZE (nimodipine oral solution) has comparable bioavailability to nimodipine oral capsules.

The following clinically significant adverse reaction appears in other sections of the labeling:

  • Hypotension [see WARNINGS AND PRECAUTIONS].

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In clinical trials of nimodipine oral capsules in patients with SAH, eleven percent (92 of 823) of nimodipinetreated patients reported adverse events compared to six percent (29 of 479) of placebo-treated patients. The most common adverse event was decreased blood pressure in 4.4% of nimodipine-treated patients. The events reported with a frequency greater than 1% are displayed in Table 1 by dose.

Table 1: Adverse Events [n (%)] reported with a frequency > 1%in four clinical trials (Study 1, Study 2, Study 3, and Study 4)

Placebo
(n=479)
Nimodipine dose every 4 hours
0.35 mg/kg
(n=82)
30 mg
(n=71)
60 mg
(n=494)
90 mg
(n=172)
120 mg
(n=4)
Decreased Blood Pressure6 (1.2)1 (1.2)019 (3.8)14 (8.1)2 (50.0)
Edema3 (0.6)002 (0.4)2 (1.2)0
Diarrhea3 (0.6)03 (4.2)03 (1.7)0
Rash3 (0.6)2 (2.4)03 (0.6)2 (1.2)0
Headache1 (0.2)01 (1.4)6 (1.2)00
Gastrointestinal Symptoms02 (2.4)002 (1.2)0
Nausea01 (1.2)1 (1.4)6 (1.2)1 (0.6)0
Dyspnea01 (1.2)0000
EKG Abnormalities001 (1.4)01 (0.6)0
Tachycardia001 (1.4)000
Bradycardia0005 (1.0)1 (0.6)0
Muscle Pain/Cramp001 (1.4)1 (0.2)1 (0.6)0
Acne001 (1.4)000
Depression001 (1.4)000

SAH is frequently accompanied by alterations in consciousness that may lead to an under-reporting of adverse experiences. As a calcium channel blocker, nimodipine may have the potential to exacerbate heart failure in susceptible patients or to interfere with A-V conduction, but these events were not observed in SAH trials.

Read the entire FDA prescribing information for Nymalize (Nimodipine Oral Solution)

© Nymalize Patient Information is supplied by Cerner Multum, Inc. and Nymalize Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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