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Obsessive Compulsive Disorder (OCD) (cont.)

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What causes obsessive compulsive disorder?

While there is no clear cause for OCD, family history and possible chemical imbalances in the brain are thought to contribute to developing the illness. While people who have relatives with the illness are at a higher risk of developing OCD, most people with the condition have no such family history. A specific genetic variation has been found to potentially double the chances of a person developing OCD. An imbalance of the chemical serotonin in the brain may also contribute to the development of this disorder. Certain life stressors, like being the victim of childhood sexual abuse, is a risk factor for developing OCD during adulthood.

How is obsessive compulsive disorder diagnosed?

Some health-care professionals will give a self-test of screening questions to people whom they suspect may have OCD. In addition to looking for symptoms of obsessions and compulsions by conducting a mental-health interview and mental-status examination, mental-health practitioners will explore the possibility that the person's symptoms are caused by another emotional disorder instead of or in addition to OCD. For example, people with addiction often have obsessions or compulsions, but those characteristics usually just involve the addiction. Individuals who suffer from narcissism may have obsessions, but those tend to be limited to self-obsession. The professional will also likely ensure that a medical examination and any other necessary tests have been done recently to consider whether there is any medical issue that could be causing any of the signs or symptoms of OCD.

What are the treatments for obsessive compulsive disorder?

Most individuals with OCD have some symptoms of the disorder indefinitely, comprised of times of improvement alternating with times of increased symptoms. The prognosis for this disorder is most favorable for sufferers who have milder symptoms that have occurred for less time and who have no other medical or mental-health issues prior to developing OCD.

Treatment of OCD includes cognitive behavioral psychotherapy, behavioral therapies, and medications. Behavioral therapies for OCD include systematic desensitization therapy, aversion therapy, rational emotive behavior therapy, and ritual prevention and exposure therapy. Prevention of rituals involves a mental-health professional helping the person with OCD endure longer and longer periods of resisting the urge to engage in compulsive behaviors. Exposure and response prevention therapy is a type of behavior modification that involves the individual getting in touch with situations that tend to increase their urge to perform compulsions then helping the person resist that urge. Cognitive/behavioral therapy begins with psycho-education of the OCD sufferer regarding their illness and works towards changing the negative ways of thinking and behaving associated with the anxiety involved with obsessive compulsive disorder.

Selective serotonin reuptake inhibitors (SSRIs) are the medications that are most often used to treat OCD. These medications increase the amount of the neurochemical serotonin in the brain. (Brain serotonin levels are thought to be low in OCD.) SSRIs work by selectively inhibiting (blocking) serotonin reuptake in the brain, specifically at the synapse, the place where brain cells (neurons) connect to each other. Serotonin is one of the brain chemicals that carries messages across synapses from one neuron to another.

SSRIs work by keeping serotonin present in high concentrations in the synapses. These medications do so by preventing the reuptake of serotonin back into the nerve cell that is transmitting an impulse. Since the reuptake of serotonin is responsible for turning off the production of new serotonin, the serotonin message keeps on coming through. It is thought that this helps activate cells that have been deactivated by OCD, thereby relieving the symptoms of the condition.

SSRIs have fewer side effects than clomipramine, which is an older medication that is actually thought to be somewhat more effective in treating OCD but might cause orthostatic hypotension (a sudden drop in blood pressure when sitting up or standing that can cause fainting) and heart-rhythm disturbances. Therefore, SSRIs are often the first-line treatment for this disorder. Examples of SSRIs include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), citalopram (Celexa), fluvoxamine (Luvox), escitalopram (Lexapro), vortioxetine (Brintellix), and vilazodone (Viibryd). When the improvement that people with OCD experience is not optimal when an SSRI is the only medication prescribed, the addition of a neuroleptic medication like risperidone (Risperdal), olanzapine (Zyprexa), aripiprazole (Abilify), quetiapine (Seroquel), ziprasidone (Geodon), paliperidone (Invega), asenapine (Saphris), or lurasidone (Latuda) can sometimes help.

Some studies show that SNRI medications like venlafaxine (Effexor), duloxetine (Cymbalta), and desvenlafaxine (Pristiq) can be an effective alternative to SSRIs. These medications increase the amount of the neurochemicals serotonin, epinephrine and norepinephrine in the brain. Buspirone (Buspar) has been used by some mental-health prescribers to treat OCD and related disorders, particularly when added to other medications in an attempt to improve the response of people who did not improve optimally to one medication. However, this medication is not considered to be a primary treatment for these disorders.

SSRIs are generally well tolerated, and side effects are usually mild. The most common side effects include nausea, diarrhea, agitation, insomnia, and headache. However, these side effects generally go away within the first month of SSRI use. Some individuals experience sexual side effects, like decreased sexual desire (libido), delayed orgasm, or an inability to have an orgasm. Some patients develop tremors with SSRIs. The so-called serotonergic (meaning caused by serotonin) syndrome is a serious neurologic condition associated with the use of this group of medications that is characterized by high fevers, seizures, and heart-rhythm disturbances. This condition is very rare and has been reported only in very sick psychiatric patients taking multiple psychiatric medications.

Newer, often called atypical, neuroleptic medications like the ones named above tend to cause fewer side effects than many of the older medications in this class. The most common side effects of atypical neuroleptics include sleepiness, dizziness, dry mouth, and weight gain. Sometimes, people can be more sensitive to the effects of the sun while taking these medications and therefore should be sure to wear adequate sunblock whenever exposed to the sun. Less commonly, side effects of atypical neuroleptic medications can result in painless, although abnormal, muscle movements like tremors, stiffness, and very rarely permanent muscle twitches called tardive dyskinesia.

Mood stabilizers like carbamazepine (Tegretol), divalproex sodium (Depakote), and lamotrigine (Lamictal) are sometimes used to treat OCD, particularly in individuals who also suffer from bipolar disorder. The side effects that professionals look for tend to vary depending on which medication is being prescribed. Professionals tend to watch for mild side effects like sleepiness when using Depakote or Tegretol or stomach upset when using any of these medications. Professionals also monitor patients for serious side effects like severely low white blood cell count with Tegretol or severe autoimmune reactions like Stevens-Johnson syndrome with Depakote or Lamictal. While lithium remains a hallmark treatment for bipolar disorder, particularly in adults, studies have not indicated significant benefit for its use in treating OCD.

Studies on the effectiveness of treatment of OCD in adults have variable results. Some indicate that medications, response prevention, and CBT are equally, although only mildly to moderately, effective in treating this problem. Cognitive behavioral group psychotherapy (CBGT) has also been found to be an effective treatment for OCD.

Research on treating OCD in children and adolescents indicates that while medications are clearly effective in treating this disorder, the improvement that is experienced is quite mild. However, clomipramine tends to be more effective than the SSRIs, and the individual SSRIs tend to be equally effective as each other. Similar to adults, people under 18 years of age tend to improve more significantly when treated with a combination of medication and CBT. There is increasing evidence that deep brain stimulation may be effective in treating severe OCD that has not responded to other treatments.

Medically Reviewed by a Doctor on 1/11/2016


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