Ocrevus vs. Aubagio

Reviewed on 11/25/2019

Are Ocrevus and Aubagio the Same Thing?

Ocrevus (siponimod) and Aubagio (interferon beta-1b) Kit are used to treat relapsing forms of multiple sclerosis (MS).

Aubagio will not cure MS, it will only decrease the frequency of relapse symptoms.

Ocrevus and Aubagio belong to different drug classes. Ocrevus is a sphingosine 1-phosphate receptor modulator and Aubagio is a beta interferon made from human proteins.

Side effects of Ocrevus and Aubagio that are similar include headache.

Side effects of Ocrevus that are different from Aubagio include high blood pressure (hypertension), increased liver transaminase, falls, pain and swelling in extremities, nausea, dizziness, diarrhea, and slow heart rate.

Side effects of Aubagio that are different from Ocrevus include muscle pain or weakness, sleep problems (insomnia), stomach or abdominal pain, swelling in your hands or feet, skin rash, hives, itching, irregular menstrual periods, flu-like symptoms (chills, fever, general feeling of being unwell), increased sweating, decreased white blood cell count, injection site reactions (bruising, swelling, redness, pain, warm feeling, or leaking of fluid), stuffy nose, and irregular heartbeat.

Ocrevus may interact with “live” vaccines, cancer medications, immune-modulating drugs, immunosuppressive therapies, anti-arrhythmics, QT prolonging drugs, calcium channel blockers, other drugs that may decrease heart rate, beta-blockers, fluconazole, rifampin, carbamazepine, modafinil, or efavirenz.

Aubagio may interact with alcohol.

What Are Possible Side Effects of Ocrevus?

Common side effects of Ocrevus include:

What Are Possible Side Effects of Aubagio?

Common side effects of Aubagio include:

  • liver problems,
  • influenza,
  • hair loss or thinning hair,
  • nausea,
  • diarrhea,
  • burning or prickly feeling in your skin, or
  • numbness or tingling in your hands or feet that is different from your MS symptoms.

Tell your doctor if you have serious side effects of Aubagio including:

  • fever,
  • chills,
  • body aches,
  • flu symptoms,
  • sores in your mouth and throat,
  • itching,
  • tired feeling,
  • loss of appetite,
  • dark urine,
  • clay-colored stools,
  • yellowing of the skin or eyes,
  • fast or racing heartbeats,
  • confusion,
  • little or no urinating,
  • chest pain,
  • dry cough,
  • wheezing,
  • feeling short of breath,
  • skin redness or peeling,
  • swelling,
  • rapid weight gain, or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

What Is Ocrevus?

Ocrevus (ocrelizumab) injection is aCD20-directed cytolytic antibody indicated for the treatment of patients with relapsing or primary progressive forms of multiple sclerosis.

What Is Aubagio?

Aubagio (teriflunomide) is a pyrimidine synthesis inhibitor used to treat relapsing forms of multiple sclerosis (MS).

SLIDESHOW

What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis See Slideshow

What Drugs Interact With Ocrevus?

Ocrevus may interact with other immune-modulating or immunosuppressive therapies, including immunosuppressant doses of corticosteroids. Tell your doctor all medications and supplements you use.

What Drugs Interact With Aubagio?

Aubagio may increase exposure of ethinyl estradiol and levonorgestrel. Patients taking Coumadin (warfarin) should be closely monitored as interactions may occur. Aubagio may cause major birth defects if used during pregnancy. Pregnancy must be excluded before starting treatment with Aubagio. Pregnancy must be avoided while taking Aubagio treat relapsing forms of multiple sclerosis (MS). If Aubagio is used during pregnancy, or if the patient becomes pregnant while taking Aubagio, the drug should be discontinued immediately and an accelerated elimination procedure should be initiated. Consult your doctor before breastfeeding.

How Should Ocrevus Be Taken?

Hepatitis B virus screening is required before the first dose of Ocrevus. Pre-medicate with methylprednisolone (or an equivalent corticosteroid) and an antihistamine prior to each infusion. The starting dose of Ocrevus is 300 mg intravenous infusion, followed two weeks later by a second 300 mg intravenous infusion. Subsequent doses of Ocrevus are 600 mg intravenous infusion every 6 months.

How Should Aubagio Be Taken?

The recommended dose for Aubagio is 7 mg or 14 mg taken orally, once daily, with or without food.

QUESTION

What kind of disease is multiple sclerosis? See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Genentech. Ocrevus Product Monograph.

https://www.ocrevus.com

Genzyme Corporation. Aubagio Product Information.

www.aubagio.com/?

Health Solutions From Our Sponsors