Ocrevus vs. Gilenya

Reviewed on 11/25/2019

Are Ocrevus and Gilenya the Same Thing?

Ocrevus (ocrelizumab) injection and Gilenya (fingolimod) are used to treat relapsing forms of multiple sclerosis (MS).

Ocrevus is also used to treat primary progressive forms of multiple sclerosis (MS).

Ocrevus and Gilenya belong to different drug classes. Ocrevus is a CD20-directed cytolytic antibody and Gilenya is a sphingosine 1-phosphate receptor modulator.

Side effects of Ocrevus and Gilenya that are similar include back pain.

Side effects of Ocrevus that are different from Gilenya include upper and lower respiratory tract infections, infusion reactions (itching, rash, hives, redness, bronchospasm, swollen and sore throat, mouth pain, shortness of breath, flushing, hypotension, fever, fatigue, headache, dizziness, nausea, and fast heart rate), skin infections, depression, and pain in the extremities.

Side effects of Gilenya that are different from Ocrevus include headache, tired feeling, influenza, stuffy nose, sinus pain, diarrhea, liver transaminase elevations, and cough.

Both Ocrevus and Gilenya may interact with other immune-modulating or immunosuppressive therapies, including immunosuppressant doses of corticosteroids.

Gilenya may also interact with beta-blockers, calcium channel blockers, citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, medications for cancer, heart problems, or high blood pressure, and methadone.

What Are Possible Side Effects of Ocrevus?

Common side effects of Ocrevus include:

  • upper respiratory tract infections,
  • infusion reactions (itching, rash, hives, redness, bronchospasm, swollen and sore throat, mouth pain, shortness of breath, flushing, hypotension, fever, fatigue, headache, dizziness, nausea, and fast heart rate),
  • skin infections,
  • lower respiratory tract infections,
  • depression,
  • back pain, and
  • pain in the extremities.

What Are Possible Side Effects of Gilenya?

Common side effects of Gilenya include:

  • headache,
  • tired feeling,
  • influenza,
  • stuffy nose,
  • sinus pain,
  • diarrhea,
  • back pain,
  • liver transaminase elevations, and
  • cough.

Gilenya can affect your immune system's ability to fight an infection while you are taking the medication and for 2 months after your last dose. Tell your doctor right away if you develop signs of an infection such as:

  • persistent cough or sore throat,
  • difficulty breathing,
  • fever,
  • chills, or
  • cold/flu symptoms.

What Is Ocrevus?

Ocrevus (ocrelizumab) injection is aCD20-directed cytolytic antibody indicated for the treatment of patients with relapsing or primary progressive forms of multiple sclerosis.

What Is Gilenya?

Gilenya (fingolimod) is a sphingosine 1-phosphate receptor modulator used to treat patients with relapsing forms of multiple sclerosis (MS) to reduce the frequency of exacerbations and to delay physical disability.

SLIDESHOW

What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis See Slideshow

What Drugs Interact With Ocrevus?

Ocrevus may interact with other immune-modulating or immunosuppressive therapies, including immunosuppressant doses of corticosteroids. Tell your doctor all medications and supplements you use.

What Drugs Interact With Gilenya?

Gilenya may interact with beta-blockers, calcium channel blockers, citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, medications to control the immune system, medications for cancer, heart problems, or high blood pressure, and methadone. Tell your doctor all medications and supplements you use. Gilenya may cause fetal harm. It takes approximately 2 months for Gilenya to be eliminated from the body. Women should avoid pregnancy during treatment with Gilenya and for 2 months after treatment. It is not known if Gilenya passes into breast milk. Women and their doctors should decide whether to take Gilenya or breastfeed. Women should not do both.

How Should Ocrevus Be Taken?

Hepatitis B virus screening is required before the first dose of Ocrevus. Pre-medicate with methylprednisolone (or an equivalent corticosteroid) and an antihistamine prior to each infusion. The starting dose of Ocrevus is 300 mg intravenous infusion, followed two weeks later by a second 300 mg intravenous infusion. Subsequent doses of Ocrevus are 600 mg intravenous infusion every 6 months.

How Should Gilenya Be Taken?

The recommended dose for Gilenya is 0.5 mg orally once daily, with or without food.

QUESTION

What kind of disease is multiple sclerosis? See Answer
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References
Genentech. Ocrevus Product Monograph.

https://www.ocrevus.com

Novartis. Gilenya Product Information

https://www.gilenya.com

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