Ocrevus vs. Lemtrada

Reviewed on 11/25/2019

Are Ocrevus and Lemtrada the Same Thing?

Ocrevus (ocrelizumab) injection and Lemtrada (alemtuzumab) are used to treat relapsing forms of multiple sclerosis (MS).

Ocrevus is also used to treat primary progressive forms of multiple sclerosis (MS).

Because of its safety profile, the use of Lemtrada should generally be reserved for patients who have had an inadequate response to two or more drugs indicated for the treatment of MS.

Ocrevus and Lemtrada belong to different drug classes. Ocrevus is a CD20-directed cytolytic antibody and Lemtrada is a recombinant humanized IgG1 kappa monoclonal antibody.

Side effects of Ocrevus and Lemtrada that are similar include upper respiratory tract infection, back pain, and pain in the extremities.

Side effects of Ocrevus that are different from Lemtrada include lower respiratory tract infections, infusion reactions (itching, rash, hives, redness, bronchospasm, swollen and sore throat, mouth pain, shortness of breath, flushing, hypotension, fever, fatigue, headache, dizziness, nausea, and fast heart rate), skin infections, and depression.

Side effects of Lemtrada that are different from Ocrevus include rash, headache, fever, runny nose, sore throat, nasal congestion, nausea, urinary tract infection (UTI), fatigue, insomnia, herpes viral infection, hives, itching, thyroid gland disorders, fungal infection, joint pain, diarrhea, sinus infection, mouth and throat pain, numbness or tingling, dizziness, abdominal pain, flushing of the face/neck/chest, vomiting, cough, chills, changes in sense of taste, flu symptoms, skin swelling, indigestion, blood in the urine, shortness of breath, fast heartbeat, anxiety, weakness, and muscle pain.

Ocrevus may interact with other immune-modulating or immunosuppressive therapies, including immunosuppressant doses of corticosteroids.

Lemtrada may interact with other drugs.

What Are Possible Side Effects of Ocrevus?

Common side effects of Ocrevus include:

  • upper respiratory tract infections,
  • infusion reactions (itching, rash, hives, redness, bronchospasm, swollen and sore throat, mouth pain, shortness of breath, flushing, hypotension, fever, fatigue, headache, dizziness, nausea, and fast heart rate),
  • skin infections,
  • lower respiratory tract infections,
  • depression,
  • back pain, and
  • pain in the extremities.

What Are Possible Side Effects of Lemtrada?

Common side effects of Lemtrada include:

  • rash,
  • headache,
  • fever,
  • runny nose,
  • sore throat,
  • nasal congestion,
  • nausea,
  • urinary tract infection,
  • fatigue,
  • insomnia,
  • upper respiratory tract infection,
  • herpes viral infection,
  • hives,
  • itching,
  • thyroid gland disorders,
  • fungal infection,
  • joint pain,
  • pain in extremity,
  • back pain,
  • diarrhea,
  • sinus infection,
  • mouth and throat pain,
  • numbness or tingling, dizziness,
  • abdominal pain,
  • flushing of the face/neck/chest,
  • vomiting,
  • cough,
  • chills,
  • changes in sense of taste,
  • flu symptoms,
  • skin swelling,
  • indigestion,
  • blood in the urine,
  • shortness of breath,
  • fast heart beat,
  • anxiety,
  • weakness, or
  • muscle pain

What Is Ocrevus?

Ocrevus (ocrelizumab) injection is aCD20-directed cytolytic antibody indicated for the treatment of patients with relapsing or primary progressive forms of multiple sclerosis.

What Is Lemtrada?

Lemtrada (alemtuzumab) is a recombinant humanized IgG1 kappa monoclonal antibody used to treat patients with relapsing forms of multiple sclerosis (MS). Because of its safety profile, the use of Lemtrada should generally be reserved for patients who have had an inadequate response to two or more drugs indicated for the treatment of MS.

QUESTION

What kind of disease is multiple sclerosis? See Answer

What Drugs Interact With Ocrevus?

Ocrevus may interact with other immune-modulating or immunosuppressive therapies, including immunosuppressant doses of corticosteroids. Tell your doctor all medications and supplements you use.

What Drugs Interact With Lemtrada?

Lemtrada may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Lemtrada should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

How Should Ocrevus Be Taken?

Hepatitis B virus screening is required before the first dose of Ocrevus. Pre-medicate with methylprednisolone (or an equivalent corticosteroid) and an antihistamine prior to each infusion. The starting dose of Ocrevus is 300 mg intravenous infusion, followed two weeks later by a second 300 mg intravenous infusion. Subsequent doses of Ocrevus are 600 mg intravenous infusion every 6 months.

How Should Lemtrada Be Taken?

The recommended dosage of Lemtrada is 12 mg/day administered by intravenous infusion for 2 treatment courses: First Treatment Course: 12 mg/day on 5 consecutive days (60 mg total dose; Second Treatment Course: 12 mg/day on 3 consecutive days (36 mg total dose) administered 12 months after the first treatment course.

SLIDESHOW

What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Genentech. Ocrevus Product Monograph.

https://www.ocrevus.com

Sanofi. Lemtrada Product Information

www.lemtrada.com/?

Health Solutions From Our Sponsors