Olux Side Effects Center

Last updated on RxList: 7/6/2022
Olux Side Effects Center

What Is Olux?

Olux (clobetasol propionate) Foam is a topical (for the skin) steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Olux Foam is available in generic form.

What Are Side Effects of Olux?

Common side effects of Olux Foam include burning, stinging, itching, irritation, dryness, redness, or skin rash when first applied to the scalp/skin. This should disappear in a few days as your body adjusts to Olux Foam. Other side effects of Olux Foam include:

  • dry or cracking skin,
  • thinning or softening of your skin,
  • skin rash or irritation around your mouth,
  • swollen hair follicles,
  • temporary hair loss,
  • spider veins,
  • changes in color of treated skin,
  • blisters,
  • pimples,
  • crusting of treated skin, or
  • stretch marks.

Tell your doctor if you have severe irritation of any treated skin, or if you show signs of absorbing Olux Foam topical through your skin, such as:

  • blurred vision,
  • seeing halos around lights,
  • mood changes,
  • sleep problems (insomnia),
  • weight gain or loss,
  • puffiness in your face,
  • muscle weakness,
  • feeling tired,
  • headache,
  • swelling ankles or feet, or
  • increased thirst or urination.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Olux

Apply Olux Foam twice a day, once in the morning and once at night. Apply only enough to cover the affected areas. It is not likely that other drugs you take orally or inject will have an effect on topically applied Olux.

What Drugs, Substances, or Supplements Interact with Olux?

But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use.

Olux During Pregnancy or Breastfeeding

Olux should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk when applied to the scalp/skin. Similar medications pass into breast milk when taken by mouth. Consult your doctor before breastfeeding.

Additional Information

Our Olux (clobetasol propionate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Types of Psoriasis: Medical Pictures and Treatments See Slideshow
Olux Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain in your face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

  • burning, itching, swelling, or irritation of treated skin;
  • dry or cracking skin;
  • redness or crusting around your hair follicles;
  • spider veins;
  • stretch marks, thinning skin;
  • rash or hives;
  • acne; or
  • temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Olux (Clobetasol Propionate)


Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer
Olux Professional Information


The following adverse reactions are discussed in greater detail in other sections of the labeling:

  • Effects on Endocrine System [see WARNINGS AND PRECAUTIONS]
  • Ophthalmic Adverse Reactions [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In a controlled clinical trial involving 188 subjects with psoriasis of the scalp, there were no localized scalp adverse reactions reported in the subjects treated with OLUX Foam. In 2 controlled clinical trials with OLUX Foam in 360 subjects with psoriasis of non-scalp regions, localized adverse events that occurred in the subjects treated with OLUX Foam included application site burning (10%), application site dryness (<1%), and other application site reactions (4%).

In larger controlled trials with other clobetasol propionate formulations, the most frequently reported local adverse reactions have included burning, stinging, irritation, pruritus, erythema, folliculitis, cracking and fissuring of the skin, numbness of the fingers, skin atrophy, and telangiectasia (all less than 2%).

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Local adverse reactions to topical corticosteroids may include: striae, itching, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, and miliaria.

Ophthalmic adverse reactions may include: cataracts, glaucoma, increased intraocular pressure, and central serous chorioretinopathy.

Read the entire FDA prescribing information for Olux (Clobetasol Propionate)

© Olux Patient Information is supplied by Cerner Multum, Inc. and Olux Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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