Medical Editor: John P. Cunha, DO, FACOEP
Olux (clobetasol propionate) Foam is a topical (for the skin) steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Olux Foam is available in generic form. Common side effects of Olux Foam include burning, stinging, itching, irritation, dryness, redness, or skin rash when first applied to the scalp/skin. This should disappear in a few days as your body adjusts to Olux Foam. Other side effects of Olux Foam include:
- dry or cracking skin,
- thinning or softening of your skin,
- skin rash or irritation around your mouth,
- swollen hair follicles,
- temporary hair loss,
- spider veins,
- changes in color of treated skin,
- crusting of treated skin, or
- stretch marks.
Tell your doctor if you have severe irritation of any treated skin, or if you show signs of absorbing Olux Foam topical through your skin, such as:
- blurred vision,
- seeing halos around lights,
- mood changes,
- sleep problems (insomnia),
- weight gain or loss,
- puffiness in your face,
- muscle weakness,
- feeling tired,
- swelling ankles or feet, or
- increased thirst or urination.
Apply Olux Foam twice a day, once in the morning and once at night. Apply only enough to cover the affected areas. It is not likely that other drugs you take orally or inject will have an effect on topically applied Olux. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use. Olux should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk when applied to the scalp/skin. Similar medications pass into breast milk when taken by mouth. Consult your doctor before breastfeeding.
Our Olux (clobetasol propionate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Although the risk of serious side effects is low when clobetasol topical is applied to the skin, you should be aware of side effects that can occur if the medication is absorbed into your bloodstream.
Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing clobetasol topical through your skin, such as:
- blurred vision, or seeing halos around lights;
- mood changes;
- sleep problems (insomnia);
- weight gain, puffiness in your face; or
- muscle weakness, feeling tired.
Less serious side effects may include:
- mild skin rash, itching, burning, or redness;
- dry or cracking skin;
- thinning or softening of your skin;
- skin rash or irritation around your mouth;
- swollen hair follicles;
- temporary hair loss;
- spider veins;
- changes in color of treated skin;
- blisters, pimples, or crusting of treated skin; or
- stretch marks.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Olux (Clobetasol Propionate)
In a controlled pharmacokinetic study, 5 of 13 subjects experienced reversible suppression of the adrenals at any time during the 14 days of OLUX (clobetasol propionate) Foam therapy to at least 20% of the body surface area. Of the 13 subjects studied, 1 of 9 with psoriasis were suppressed after 14 days and all 4 of the subjects with atopic dermatitis had abnormal cortisol levels indicative of adrenal suppression at some time after starting therapy with OLUX (clobetasol propionate) Foam. (See Table 3 below.)
Table 3: Subjects with reversible HPA axis suppression at any time during treatment
|Psoriasis||1 of 9|
|Atopic Dermatitis*||4 of 4|
|*OLUX Foam is not indicated for non-scalp atopic dermatitis, as the safety and efficacy of OLUX Foam in non-scalp atopic dermatitis has not been established. Use in children under 12 years of age is not recommended.|
In a controlled clinical trial (188 subjects) with OLUX (clobetasol propionate) Foam in subjects with psoriasis of the scalp, there were no localized scalp adverse reactions reported in the OLUX (clobetasol propionate) Foam treated subjects. In two controlled clinical trials (360 subjects) with OLUX (clobetasol propionate) Foam in subjects with psoriasis of non-scalp regions, localized adverse events that occurred in the OLUX (clobetasol propionate) Foam treated subjects included application site burning (10%), application site dryness ( < 1%), and other application site reactions (4%).
In larger controlled trials with other clobetasol propionate formulations, the most frequently reported local adverse reactions have included burning, stinging, irritation, pruritus, erythema, folliculitis, cracking and fissuring of the skin, numbness of the fingers, skin atrophy, and telangiectasia (all less than 2%).
The following additional local adverse reactions have been reported with topical corticosteroids, but they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids such as OLUX (clobetasol propionate) Foam. These reactions are listed in an approximate decreasing order of occurrence: dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, striae, and miliaria.
Read the entire FDA prescribing information for Olux (Clobetasol Propionate)
© Olux Patient Information is supplied by Cerner Multum, Inc. and Olux Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.