Ondine's curse: Failure from birth of central nervous system control over breathing while asleep. There are usually no breathing problems while awake. The involuntary (autonomic) control of respiration is impaired, but the voluntary control of ventilation which operates during waking hours is generally intact.
There can, in addition, be problems with the motility of the esophagus and the colon. Reduced esophageal motility causes food to move too slowly down to the stomach. Reduced motility of the colon produces a condition called Hirschsprung disease (megacolon) with severe constipation and even obstruction. The heart rate may be abnormally slow.
The names for this disease include congenital central hypoventilation syndrome (CCHS), CCHS with Hirschsprung disease, congenital failure of autonomic control, idiopathic central alveolar hypoventilation, and central sleep apnea with severe hypoventilation.