Orapred ODT

Last updated on RxList: 3/23/2020
Orapred ODT Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Orapred ODT?

Orapred ODT (prednisolone sodium phosphate) Orally Disintegrating Tablets is indicated in the treatment of the following disease or conditions: allergic, dermatologic diseases, endocrine, gastrointestinal diseases, hematologic diseases, neoplastic, nervous system, ophthalmic conditions, conditions related to organ transplantation, pulmonary diseases, renal, rheumatologic, and specific infectious diseases. Orapred ODT is available as a generic.

What Are Side Effects of Orapred ODT?

Common side effects of Orapred ODT include:

  • sleep problems (insomnia),
  • mood changes,
  • acne,
  • dry skin,
  • thinning skin,
  • bruising or discoloration,
  • slow wound healing,
  • increased sweating,
  • headache,
  • dizziness,
  • spinning sensation,
  • nausea,
  • stomach pain,
  • bloating, or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Serious side effects of Orapred ODT include allergic disorders, endocrine changes, and infections.

Dosage for Orapred ODT

Dosage of Orapred ODT should be individualized according to the severity of the disease and the response of the patient.

What Drugs, Substances, or Supplements Interact with Orapred ODT?

Orapred ODT may interact with aspirin (taken on a daily basis or at high doses), diuretics (water pills), blood thinners, cyclosporine, insulin or oral diabetes medications, ketoconazole, rifampin, seizure medications, or "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received.

Orapred ODT During Pregnancy and Breastfeeding

If this drug is used during pregnancy, or if the patient becomes pregnant while using this drug, the patient should be informed of the potential hazard to the fetus. While taking Orapred ODT the benefits must outweigh potential harm to the infant. Orapred ODT passes into breast milk and may harm a nursing baby. Use of Orapred ODT while breastfeeding is not recommended.

Additional Information

Our Orapred ODT (prednisolone sodium phosphate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Allergies can best be described as: See Answer
Orapred ODT Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • bruising, thinning skin, or any wound that will not heal;
  • severe depression, changes in personality, unusual thoughts or behavior;
  • new or unusual pain in an arm or leg or in your back;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • a seizure (convulsions); or
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling.

Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • fluid retention (swelling in your hands or ankles);
  • dizziness, spinning sensation;
  • changes in your menstrual periods;
  • headache;
  • muscle pain or weakness; or
  • stomach discomfort, bloating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Orapred ODT (Prednisolone Sodium Phosphate)


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Orapred ODT Professional Information


Common adverse reactions for corticosteroids include fluid retention, alteration in glucose tolerance, elevation in blood pressure, behavioral and mood changes, increased appetite and weight gain.

Allergic Reactions: Anaphylactoid reaction, anaphylaxis, angioedema

Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis

Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scalp, edema, facial erythema, hyper or hypo-pigmentation, impaired wound healing, increased sweating, petechiae and ecchymoses, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria

Endocrine: Abnormal fat deposits, decreased carbohydrate tolerance, development of Cushingoid state, hirsutism, manifestations of latent diabetes mellitus and increased requirements for insulin or oral hypoglycemic agents in diabetics, menstrual irregularities, moon facies, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery or illness), suppression of growth in children

Fluid and Electrolyte Disturbances: Fluid retention, potassium loss, hypertension, hypokalemic alkalosis, sodium retention

Gastrointestinal: Abdominal distention; elevation in serum liver enzyme levels (usually reversible upon discontinuation); hepatomegaly, hiccups, malaise, nausea, pancreatitis; peptic ulcer with possible perforation and hemorrhage; ulcerative esophagitis

General: Increased appetite and weight gain

Metabolic: Negative nitrogen balance due to protein catabolism

Musculoskeletal: Aseptic necrosis of femoral and humeral heads; charcot-like arthropathy, loss of muscle mass; muscle weakness; osteoporosis; pathologic fracture of long bones; steroid myopathy; tendon rupture; vertebral compression fractures

Neurological: Arachnoiditis, convulsions; depression, emotional instability, euphoria, headache; increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment; insomnia, meningitis, mood swings, neuritis, neuropathy, paraparesis/ paraplegia, paresthesia, personality changes, sensory disturbances, vertigo

Ophthalmic: Exophthalmos; glaucoma; increased intraocular pressure; posterior subcapsular cataracts

Reproductive: Alteration in motility and number of spermatozoa

Postmarketing Experience

Adverse reactions have been identified during post approval use of Orapred ODT. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The postmarketing experience has not raised new safety concerns beyond those already established for immediate-release prednisolone.

Read the entire FDA prescribing information for Orapred ODT (Prednisolone Sodium Phosphate)

© Orapred ODT Patient Information is supplied by Cerner Multum, Inc. and Orapred ODT Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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