Orphenadrine Citrate Side Effects Center

Last updated on RxList: 7/18/2022
Orphenadrine Citrate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Orphenadrine Citrate?

Orphenadrine Citrate Injection is an anticholinergic drug indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine citrate is available in generic form.

What Are Side Effects of Orphenadrine Citrate?

Common side effects orphenadrine citrate include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Orphenadrine Citrate

The adult dose of orphenadrine citrate is one 2 mL vial (60 mg) intravenously or intramuscularly; may be repeated every 12 hours.

What Drugs, Substances, or Supplements Interact with Orphenadrine Citrate?

Orphenadrine citrate may interact with other drugs. Tell your doctor all medications and supplements you use.

Orphenadrine Citrate During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using orphenadrine citrate; it is unknown how it will affect a fetus. Consult your doctor before breastfeeding.

Additional Information

Our Orphenadrine Citrate Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Orphenadrine Citrate Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using orphenadrine and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • painful or difficult urination;
  • little or no urination;
  • confusion, anxiety, agitation, tremors, hallucinations; or
  • pounding heartbeats or fluttering in your chest.

Common side effects may include:

  • dizziness, drowsiness, weakness;
  • nausea, vomiting;
  • dry mouth; or
  • constipation.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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Orphenadrine Citrate Professional Information

SIDE EFFECTS

Adverse reactions of orphenadrine are mainly due to the mild anti- cholinergic action of orphenadrine, and are usually associated with higher dosage. Dryness of the mouth is usually the first adverse effect to appear. When the daily dose is increased, possible adverse effects include: tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilatation of pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, hypersensitivity reactions, pruritus, hallucinations, agitation, tremor, gastric irritation, and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of mental confusion. These adverse reactions can usually be eliminated by reduction in dosage. Very rare cases of aplastic anemia associated with the use of orphenadrine tablets have been reported. No causal relationship has been established.

Rare instances of anaphylactic reaction have been reported associated with the intramuscular injection of orphenadrine citrate injection.

Drug Abuse And Dependence

Orphenadrine has been chronically abused for its euphoric effects. The mood elevating effects may occur at therapeutic doses of orphenadrine.

Read the entire FDA prescribing information for Orphenadrine Citrate (Orphenadrine Citrate for Injection)

© Orphenadrine Citrate Patient Information is supplied by Cerner Multum, Inc. and Orphenadrine Citrate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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