Orphengesic Side Effects Center

Last updated on RxList: 7/6/2022
Orphengesic Side Effects Center

What Is Orphengesic?

Orphengesic (orphenadrine citrate, aspirin and caffeine) is a combination muscle relaxant, pain reliever, and stimulant used for relief of mild to moderate pain of acute musculoskeletal disorders. Orphengesic is also used as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. The brand name Orphengesic is discontinued, but generic versions may be available.

What Are Side Effects of Orphengesic?

Common side effects of Orphengesic (orphenadrine citrate, aspirin and caffeine) include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Orphengesic

The adult dose of Orphengesic is 1/2 to 1 tablet 3 to 4 times daily.

What Drugs, Substances, or Supplements Interact with Orphengesic?

Orphengesic may interact with other drugs. Tell your doctor all medications and supplements you use.

Orphengesic During Pregnancy and Breastfeeding

It is unknown if Orphengesic could be harmful to a fetus, Tell your doctor if you are pregnant or plan to become pregnant before starting treatment. Consult your doctor before breastfeeding.

Additional Information

Our Orphengesic (orphenadrine citrate, aspirin and caffeine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Orphengesic Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • confusion, anxiety;
  • fast or pounding heartbeats, fluttering in your chest;
  • tremors;
  • little or no urination;
  • eye pain, vision problems; or
  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • dry mouth;
  • blurred vision;
  • dizziness, drowsiness, weakness;
  • headache; or
  • nausea, vomiting, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Orphengesic (Orphenadrine Citrate, Asprin and Caffeine Tablets)


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Orphengesic Professional Information


Side effects of Orphengesic Forte Tablets are those seen with aspirin and caffeine or those usually associated with mild anti-cholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatosis. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of orphenadrine citrate, aspirin and caffeine has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Orphengesic Forte Tablets. Some patients may experience transient episodes of light-headedness, dizziness or syncope.


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Read the entire FDA prescribing information for Orphengesic (Orphenadrine Citrate, Asprin and Caffeine Tablets)

© Orphengesic Patient Information is supplied by Cerner Multum, Inc. and Orphengesic Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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