Oxacillin Side Effects Center

Last updated on RxList: 3/16/2022
Oxacillin Side Effects Center

What Is Oxacillin?

Oxacillin (Brand name: Bactocil) is a penicillin-type antibiotic used to treat many different types of infections caused by bacteria, such as a staphylococcal (also called "staph") infection. Oxacillin is available in generic form.

What Are Side Effects of Oxacillin?

Common side effects of Oxacillin include pain at the injection site if injected into a muscle, nausea, vomiting, stomach pain, vaginal itching or discharge, headache, swollen/black/"hairy" tongue, or thrush (white patches or inside your mouth or throat).

Dosage for Oxacillin

For mild to moderate infections, the dose of oxacillin is 250-500 mg administered intravenously every 4-6 hours. For severe infections, 1g is administered intravenously every 4-6 hours.

What Drugs, Substances, or Supplements Interact with Oxacillin?

Oxacillin may interact with methotrexate or probenecid. Tell your doctor all medications you use.

Oxacillin During Pregnancy or Breastfeeding

During pregnancy, oxacillin should be used only when prescribed. This drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Oxacillin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Oxacillin Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives, itching; wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

An allergic reaction to oxacillin can occur right after you use the medicine, or you may have a delayed reaction.

An immediate allergic reaction can occur within 48 hours after you use oxacillin, and may cause fever with an itchy skin rash.

A delayed reaction may occur past 48 hours and up to 4 weeks after you use oxacillin. Symptoms of a delayed reaction may include fever with swollen glands, rash or itching, joint pain, stomach pain, and a general ill feeling.

Call your doctor or seek medical attention if you think you may be having an allergic reaction. Also call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • nausea, vomiting;
  • bruising or swelling around the IV needle;
  • kidney problems--little or no urination, painful or difficult urination, red or pink urine;
  • liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low white blood cell counts--fever, chills, sore throat, swollen gums, mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing.

Common side effects may include:

  • nausea, upset stomach, vomiting, mild diarrhea;
  • vaginal itching or discharge;
  • swollen, black, or "hairy" tongue; or
  • thrush (white patches or inside your mouth or throat).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Oxacillin (Oxacillin for Injection)


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Body as a Whole

The reported incidence of allergic reactions to penicillin ranges from 0.7 to 10 percent (see WARNINGS). Sensitization is usually the result of treatment but some individuals have had immediate reactions when first treated. In such cases, it is thought that the patients may have had prior exposure to the drug via trace amounts present in milk and vaccines.

Two types of allergic reactions to penicillins are noted clinically, immediate and delayed.

Immediate reactions usually occur within 20 minutes of administration and range in severity from urticaria and pruritus to angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse and death. Such immediate anaphylactic reactions are very rare (see WARNINGS) and usually occur after parenteral therapy but have occurred in patients receiving oral therapy. Another type of immediate reaction, an accelerated reaction, may occur between 20 minutes and 48 hours after administration and may include urticaria, pruritus, and fever. Although laryngeal edema, laryngospasm, and hypotension occasionally occur, fatality is uncommon. Delayed allergic reactions to penicillin therapy usually occur after 48 hours and sometimes as late as 2 to 4 weeks after initiation of therapy.

Manifestations of this type of reaction include serum sickness-like symptoms (i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain) and various skin rashes. Nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, and other symptoms of gastrointestinal irritation may occur, especially during oral penicillin therapy.

Nervous System Reactions

Neurotoxic reactions similar to those observed with penicillin G may occur with large intravenous doses of oxacillin (oxacillin (oxacillin for injection) for injection) , especially with patients with renal insufficiency.

Urogenital Reactions

Renal tubular damage and interstitial nephritis have been associated infrequently with the administration of oxacillin (oxacillin (oxacillin for injection) for injection) . Manifestations of this reaction may include rash, fever, eosinophilia, hematuria, proteinuria, and renal insufficiency.

Gastrointestinal Reactions

Pseudomembranous colitis has been reported with the use of oxacillin (oxacillin (oxacillin for injection) for injection) . The onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see WARNINGS).

Metabolic Reactions

Hepatotoxicity, characterized by fever, nausea, and vomiting associated with abnormal liver function tests, mainly elevated SGOT levels, has been associated with the use of oxacillin (oxacillin (oxacillin for injection) for injection) .

Read the entire FDA prescribing information for Oxacillin (Oxacillin for Injection)

© Oxacillin Patient Information is supplied by Cerner Multum, Inc. and Oxacillin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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