Oxbryta vs. Hydrea

Reviewed on 1/27/2021

Are Oxbryta and Hydrea the Same Thing?

Oxbryta (voxelotor) and Hydrea (hydroxyurea) are used to treat sickle cell disease.

Hydrea is also used to treat melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and primary squamous cell (epidermoid) carcinomas of the head and neck.

Oxbryta and Hydrea belong to different drug classes. Oxbryta is a hemoglobin S polymerization inhibitor and Hydrea is an antineoplastic (anti-cancer) agent.

Side effects of Oxbryta and Hydrea that are similar include headache, diarrhea, nausea, and rash.

Side effects of Oxbryta that are different from Hydrea include stomach/abdominal pain, tiredness/fatigue, and fever.

Side effects of Hydrea that are different from Oxbryta include vomiting, upset stomach, constipation, skin changes such as peeling or discoloration, flu-like symptoms, hair loss, dizziness, drowsiness, and weight gain.

Oxbryta may interact with strong CYP3A4 inhibitors, fluconazole, strong or moderate CYP3A4 inducers, and midazolam.

Hydrea may interact with didanosine, stavudine, and an interferon.

What Are Possible Side Effects of Oxbryta?

Common side effects of Oxbryta include:

  • headache,
  • diarrhea,
  • stomach/abdominal pain,
  • nausea,
  • tiredness/fatigue,
  • rash, and
  • fever

What Are Possible Side Effects of Hydrea?

Common side effects of Hydrea include:

  • nausea,
  • vomiting,
  • upset stomach,
  • diarrhea,
  • constipation,
  • skin changes such as peeling or discoloration,
  • flu-like symptoms,
  • hair loss,
  • rash,
  • headache,
  • dizziness,
  • drowsiness, or
  • weight gain.

Serious side effects of Hydrea include:

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What Is Oxbryta?

Oxbryta (voxelotor) is a hemoglobin S polymerization inhibitor used to treat sickle cell disease in adults and pediatric patients 12 years of age and older.

What Is Hydrea?

Hydrea (hydroxyurea) is an antineoplastic (anti-cancer) agent used to treat melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and primary squamous cell (epidermoid) carcinomas of the head and neck. Hydrea is available in generic form.

What Drugs Interact With Oxbryta?

Oxbryta may interact with other medicines such as:

  • strong CYP3A4 inhibitors,
  • fluconazole,
  • strong or moderate CYP3A4 inducers, and
  • midazolam

Tell your doctor all medications and supplements you use.

What Drugs Interact With Hydrea?

Hydrea may interact with didanosine, stavudine, or an interferon.

Tell your doctor all medications and supplements you use.

How Should Oxbryta be Taken?

The recommended dosage of Oxbryta is 1,500 mg orally once daily with or without food.

How Should Hydrea be Taken?

Hydrea (hydroxyurea) is available in 500 mg tablets. Dosage depends on the problem being treated; the prescribing doctor will determine dosage.

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References
Global Blood Therapeutics, Inc. Oxbryta Product Information.

https://oxbryta.com/

FDA. Hydrea Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/016295Orig1s047,s048Lbl.pdf

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