Oxervate

Last updated on RxList: 11/11/2019
Oxervate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 11/11/2019

What Is Oxervate?

Oxervate (cenegermin-bkbj) is a recombinant human nerve growth factor indicated for the treatment of neurotrophic keratitis.

What Are Side Effects for Oxervate?

Common side effects of Oxervate include:

  • eye pain,
  • eye redness,
  • eye inflammation, and
  • increased tearing

Dosage for Oxervate

The dose of Oxervate is one drop in the affected eye(s), 6 times per day at 2-hour intervals, for eight weeks. Contact lenses should be removed before applying Oxervate, and patients should wait 15 minutes after instillation of the dose before reinserting the contact lenses into the eyes.

What Drugs, Substances, or Supplements Interact with Oxervate?

Oxervate may interact with other topical ophthalmic products. Administer Oxervate 15 minutes prior to using any eye ointment, gel or other viscous eye drops. Tell your doctor all medications and supplements you use.

Oxervate During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Oxervate; it is unknown how it would affect a fetus. It is unknown if Oxervate passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Oxervate (cenegermin-bkbj) Ophthalmic Solution for Topical Ophthalmic Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

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Oxervate Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include:

  • eye pain or redness;
  • eye swelling; or
  • watery eyes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Oxervate (Cenegermin-bkbj Ophthalmic Solution)

SLIDESHOW

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Oxervate Professional Information

SIDE EFFECTS

Clinical Studies Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

In two clinical trials of patients with neurotrophic keratitis, a total of 101 patients received cenegermin-bkbj eye drops at 20 mcg/mL at a frequency of 6 times daily in the affected eye(s) for a duration of 8 weeks. The mean age of the population was 61 to 65 years of age (18 to 95). The majority of the treated patients were female (61%). The most common adverse reaction was eye pain following instillation which was reported in approximately 16% of patients. Other adverse reactions occurring in 1-10% of OXERVATE patients and more frequently than in the vehicle-treated patients included corneal deposits, foreign body sensation, ocular hyperemia, ocular inflammation and tearing.

Read the entire FDA prescribing information for Oxervate (Cenegermin-bkbj Ophthalmic Solution)

© Oxervate Patient Information is supplied by Cerner Multum, Inc. and Oxervate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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