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Ozempic vs. Tresiba

Are Ozempic and Tresiba the Same Thing?

Ozempic (semaglutide) Injection and Tresiba (insulin degludec injection) are used to treat diabetes.

Ozempic is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is not indicated for use in treating type 1 diabetes.

Tresiba is used to treat both type 1 diabetes and type 2 diabetes.

Ozempic and Tresiba are different types of diabetes medications. Ozempic is a glucagon-like peptide 1 (GLP-1) receptor agonist and Tresiba is a long-acting human insulin analog.

Side effects of Ozempic and Tresiba that are similar include diarrhea and stomach/abdominal upset or pain.

Side effects of Ozempic that are different from Tresiba include nausea, vomiting, and constipation.

Side effects of Tresiba that are different from Ozempic include low blood sugar (hypoglycemia), allergic reactions, injection site reactions, body fat redistribution (lipodystrophy), itching, rash, swelling, weight gain, runny or stuffy nose, upper respiratory tract infection, headache, or sinusitis.

Both Ozempic and Tresiba may interact with insulin secretagogues or insulin.

Ozempic may also interact with other oral medications taken at the same time.

Tresiba may also interact with beta-blockers, clonidine, guanethidine, reserpine, other antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, lithium salts, or pentamidine.

What Are Possible Side Effects of Ozempic?

Common side effects of Ozempic include:

What Are Possible Side Effects of Tresiba?

Common side effects of Tresiba include:

  • low blood sugar (hypoglycemia),
  • allergic reactions,
  • injection site reactions,
  • body fat redistribution (lipodystrophy),
  • itching,
  • rash,
  • swelling,
  • weight gain,
  • runny or stuffy nose,
  • upper respiratory tract infection,
  • headache,
  • sinusitis,
  • upset stomach or stomach pain, and
  • diarrhea.

What Is Ozempic?

Ozempic (semaglutide) Injection is a glucagon-like peptide 1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

What Is Tresiba?

Tresiba (insulin degludec injection) is a long-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.

QUESTION

______________ is another term for type 2 diabetes. See Answer

What Drugs Interact With Ozempic?

Ozempic may interact with an insulin secretagogue or insulin, and other oral medications taken at the same time. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Ozempic; it is unknown how it would affect a fetus. It is unknown if Ozempic passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Tresiba?

Tresiba may interact with other insulin products, beta-blockers, clonidine, guanethidine, reserpine, other antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, lithium salts, or pentamidine. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while taking Tresiba. During pregnancy, Tresiba should only be taken if prescribed. It is unknown if Tresiba passes into breast milk. Women with diabetes who are nursing may require adjustments in insulin dose, meal plan, or both. Consult your doctor before breastfeeding.

How Should Ozempic Be Taken?

The initial dose of Ozempic is 0.25mg once weekly. After 4 weeks, increase the dose to 0.5 mg once weekly. If after at least 4 weeks additional glycemic control is needed, increase to 1mg once weekly.

How Should Tresiba Be Taken?

The dose of Tresiba is individualized based on type of diabetes, metabolic needs, blood glucose monitoring results, and glycemic control goal.

SLIDESHOW

Type 2 Diabetes Diagnosis, Treatment, Medication See Slideshow
Reviewed on 3/22/2019
References

Novo Nordisk. Ozempic Product Information.
https://www.ozempic.com
Novo Nordisk. Tresiba Product Information.
https://www.tresibapro.com
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