Padcev

Last updated on RxList: 11/15/2021
Padcev Patient Information Including Side Effects

Brand Names: Padcev

Generic Name: enfortumab vedotin

What is enfortumab vedotin (Padcev)?

Enfortumab vedotin is used to treat cancer of the bladder or urinary tract in adults.

This medicine is used when the cancer is advanced, has spread to other parts of the body (metastatic), or cannot be removed with surgery.

Enfortumab vedotin is usually given after other treatments such as immunotherapy or platinum cancer medicine.

Enfortumab vedotin may also be used for purposes not listed in this medication guide.

What are the possible side effects of enfortumab vedotin (Padcev)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have symptoms of high blood sugar:

Also call your doctor at once if you have:

  • numbness, tingling, or burning pain in your hands or feet;
  • pain, redness, and peeling skin on your hands or feet;
  • a severe skin rash with itching, scaling, or blisters;
  • severely dry eyes, vision problems; or
  • redness, itching, swelling, or discomfort where the medicine was injected.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • numbness or tingling;
  • muscle weakness;
  • feeling tired;
  • nausea, loss of appetite, diarrhea;
  • rash, dry skin;
  • hair loss; or
  • changes in your sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about enfortumab vedotin (Padcev)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

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Padcev Patient Information including How Should I Take

What should I discuss with my healthcare provider before receiving enfortumab vedotin (Padcev)?

Tell your doctor if you have ever had:

Enfortumab vedotin can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, do not use enfortumab vedotin if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using enfortumab vedotin.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because enfortumab vedotin can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 3 weeks after your last dose.

How is enfortumab vedotin given (Padcev)?

Enfortumab vedotin is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 30 minutes to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when enfortumab vedotin is injected.

Enfortumab vedotin is given in a 28-day treatment cycle. You may need to use the medicine only on certain days of each cycle. Your doctor will determine how long to treat you with this medicine.

Enfortumab vedotin can cause high blood sugar (hyperglycemia) even if you have never had it before or if you are not diabetic. Severe hyperglycemia may be life-threatening. Your blood sugar may need to be checked often.

Enfortumab vedotin can also cause dry eyes. Your doctor may tell you to use artificial-tear eye drops to help prevent dry eyes.

Padcev Patient Information including If I Miss a Dose

What happens if I miss a dose (Padcev)?

Call your doctor for instructions if you miss an appointment for your enfortumab vedotin injection.

What happens if I overdose (Padcev)?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving enfortumab vedotin (Padcev)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect enfortumab vedotin (Padcev)?

Some drugs can affect your blood levels of enfortumab vedotin, which may increase side effects. Tell your doctor about all your other medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information (Padcev)?

Your pharmacist can provide more information about enfortumab vedotin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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