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Paget's Disease (cont.)

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What are the types of Paget's disease?

There are two types of Paget's disease of bone. When a single site of bone is affected by Paget's disease, it is referred to as the monostotic type. When multiple sites of bone are affected by Paget's disease, it is referred to as the polyostotic type.

What causes Paget's disease?

It is not known what causes Paget's disease. Paget's disease is felt to be a disease of a particular cell that is responsible for bone resorption, the osteoclast.

What are risk factors for Paget's disease?

The onset of Paget's disease is typically after 55 years of age. Recently, certain genes have been associated with Paget's disease, including the Sequestrosome 1 gene on chromosome 5. Virus infection may be necessary to trigger Paget's disease in people who have inherited the genetic tendency to develop the condition by having these genes. Paget's disease is inherited in approximately one-third of patients. Therefore, it is not uncommon for a patient with the condition to have a family history of the disease.

Who discovered Paget's disease?

Paget's disease is named after the English surgeon Sir James Paget, who described the condition in 1877. Paget also discovered the worm that causes trichinosis and described what is called Paget's disease of the breast. Together with Rudolph Virchow in Germany, Paget was one of the founders of pathology.

Medically Reviewed by a Doctor on 2/28/2017


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