Paget's Disease (cont.)
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Catherine Burt Driver, MD
Catherine Burt Driver, MD, is board certified in internal medicine and rheumatology by the American Board of Internal Medicine. Dr. Driver is a member of the American College of Rheumatology. She currently is in active practice in the field of rheumatology in Mission Viejo, Calif., where she is a partner in Mission Internal Medical Group.
In this Article
- Paget's disease facts
- What is Paget's disease?
- What are the types of Paget's disease?
- What causes Paget's disease?
- What are risk factors for Paget's disease?
- Who discovered Paget's disease?
- What are Paget's disease symptoms and signs?
- What specialties of doctors diagnose and treat Paget's disease?
- How do health care professionals make a diagnosis of Paget's disease?
- What is the medical treatment for Paget's disease?
- Are there home remedies for Paget's disease?
- What are complications of Paget's disease?
- What is the prognosis for Paget's disease?
- Is it possible to prevent Paget's disease?
- Where can I find more information about Paget's disease?
- Find a local Rheumatologist in your town
What are the types of Paget's disease?
There are two types of Paget's disease of bone. When a single site of bone is affected by Paget's disease, it is referred to as the monostotic type. When multiple sites of bone are affected by Paget's disease, it is referred to as the polyostotic type.
What causes Paget's disease?
It is not known what causes Paget's disease. Paget's disease is felt to be a disease of a particular cell that is responsible for bone resorption, the osteoclast.
What are risk factors for Paget's disease?
The onset of Paget's disease is typically after 55 years of age. Recently, certain genes have been associated with Paget's disease, including the Sequestrosome 1 gene on chromosome 5. Virus infection may be necessary to trigger Paget's disease in people who have inherited the genetic tendency to develop the condition by having these genes. Paget's disease is inherited in approximately one-third of patients. Therefore, it is not uncommon for a patient with the condition to have a family history of the disease.
Who discovered Paget's disease?
Paget's disease is named after the English surgeon Sir James Paget, who described the condition in 1877. Paget also discovered the worm that causes trichinosis and described what is called Paget's disease of the breast. Together with Rudolph Virchow in Germany, Paget was one of the founders of pathology.
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