Pamelor vs. Lyrica

Are Pamelor and Lyrica the Same Thing?

Pamelor (nortriptyline HCl) and Lyrica (pregabalin) are used to treat neuropathic (nerve) pain.

Pamelor is used off-label for nerve pain. Pamelor is primarily used to treat depression.

Lyrica is also used to treat partial onset seizures in adults and to treat fibromyalgia.

Pamelor and Lyrica belong to different drug classes. Pamelor is a tricyclic antidepressant and Lyrica is an anti-epileptic drug (anticonvulsant).

Side effects of Pamelor and Lyrica that are similar include constipation, weight changes, dizziness, blurred vision, or loss of balance or coordination.

Side effects of Pamelor that are different from Lyrica include fast heart rate, urinary retention, dry mouth, tingly feeling, weakness, unpleasant taste, nausea, ringing in your ears, breast swelling (in men or women), decreased sex drive, impotence, or difficulty having an orgasm.

Side effects of Lyrica that are different from Pamelor include drowsiness, dry mouth, edema (fluid retention), breast swelling, tremors, or problems with memory or concentration.

Both Pamelor and Lyrica may interact with alcohol or other drugs that make you sleepy or slow your breathing (sleeping pills, narcotics, muscle relaxers, or medicines for anxiety or seizures).

Pamelor may also interact with bupropion, cimetidine, reserpine, St. John's wort, terbinafine, other antidepressants or medications to treat mental illness, bladder or urinary medicines, bronchodilators, cold or allergy medicines that contain an antihistamine, medications for Parkinson's disease; medications to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome; decongestants, diet pills, stimulants, or heart rhythm medications.

Lyrica may also interact with oral diabetes medicines or ACE inhibitors.

Do not stop using Pamelor or Lyrica suddenly, or you could have unpleasant withdrawal symptoms.

What Are Possible Side Effects of Pamelor?

Common side effects of Pamelor include:

  • fast heart rate,
  • blurred vision,
  • urinary retention,
  • dry mouth,
  • constipation,
  • weight gain or loss,
  • dizziness upon standing (orthostatic hypotension),
  • tingly feeling,
  • weakness,
  • lack of coordination,
  • unpleasant taste,
  • nausea,
  • ringing in your ears,
  • breast swelling (in men or women),
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm.

What Are Possible Side Effects of Lyrica?

Common side effects of Lyrica include:

  • drowsiness,
  • dry mouth,
  • dizziness,
  • blurred vision,
  • constipation,
  • weight gain,
  • trouble urinating,
  • headache,
  • increased hunger, and
  • changes in taste.

What Is Pamelor?

Pamelor (nortriptyline HCl) is an antidepressant that is used to treat mental/mood problems such as depression.

What Is Lyrica?

Lyrica (pregabalin) is an anti-epileptic drug (anticonvulsant) used for neuropathic (nerve) pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and for treating partial onset seizures in adults, and fibromyalgia.

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What Drugs Interact With Pamelor?

Pamelor may interact with narcotic pain medicines.

Pamelor may also interact with other drugs that make you sleepy or slow your breathing (sleeping pills, muscle relaxers, or medicines for anxiety, depression, or seizures), bupropion, cimetidine, reserpine, St. John's wort, terbinafine, other antidepressant or medication to treat mental illness, bladder or urinary medicines, bronchodilators, cold or allergy medicines that contain an antihistamine, medications for Parkinson's disease; medications to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome; decongestants, diet pills, stimulants, or heart rhythm medications.

Do not stop using Pamelor suddenly, or you could have unpleasant withdrawal symptoms.

What Drugs Interact With Lyrica?

Lyrica (pregabalin) is an anti-epileptic drug (anticonvulsant) used for neuropathic (nerve) pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and for treating partial onset seizures in adults, and fibromyalgia.

How Should Pamelor Be Taken?

Pamelor is administered orally in the form of capsules or liquid. Lower than usual dosages are recommended for elderly patients and adolescents.

How Should Lyrica Be Taken?

The recommended dose of Lyrica is 75-600 mg daily. Alcohol and drugs that cause sedation may increase the sedative effects of Lyrica. There are no adequate studies of Lyrica in pregnant women. If you become pregnant, your name may be listed on a pregnancy registry to track the outcome of the pregnancy and to evaluate any effects of Lyrica on the baby. It is unknown if Lyrica passes into breast milk or if it could harm a nursing baby. Breastfeeding while using Lyrica is not recommended.

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References

Pfizer. Lyrica Prescribing Information.
https://www.lyrica.com/
FDA. Pamelor Product Information
https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/018012s27lbl.pdf

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