Pamelor vs. Oleptro

Are Pamelor and Oleptro the Same Thing?

Pamelor (nortriptyline HCl) and Oleptro (trazodone hydrochloride extended-release tablets) are antidepressants used to treat depression.

Oleptro (trazodone hydrochloride extended-release tablets) is a triazolopyridine antidepressant used to treat major depressive disorder (MDD) in adults.

Pamelor and Oleptro are different types of antidepressants. Pamelor is a tricyclic antidepressant and Oleptro is a triazolopyridine antidepressant.

Side effects of Pamelor and Oleptro that are similar include blurred vision, dry mouth, constipation, dizziness, nausea, or change in sexual interest/ability (decreased sex drive, impotence, or difficulty having an orgasm).

Side effects of Pamelor that are different from Oleptro include fast heart rate, urinary retention, weight gain or loss, tingly feeling, weakness, lack of coordination, unpleasant taste, ringing in your ears, or breast swelling (in men or women).

Side effects of Oleptro that are different from Pamelor include drowsiness, sedation, lightheadedness, constipation, headache, or vomiting.

Both Pamelor and Oleptro may interact with alcohol or other drugs that make you sleepy or slow your breathing (sleeping pills, narcotics, muscle relaxers, or medicines for anxiety or seizures).

Pamelor may also interact with bupropion, cimetidine, reserpine, St. John's wort, terbinafine, other antidepressants or medications to treat mental illness, bladder or urinary medicines, bronchodilators, cold or allergy medicines that contain an antihistamine, medications for Parkinson's disease; medications to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome; decongestants, diet pills, stimulants, or heart rhythm medications.

Oleptro may also interact with monoamine oxidase inhibitors (MAOIs), barbiturates, ritonavir, ketoconazole, indinavir, itraconazole, digoxin, serotonergic drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, other drugs affecting coagulation or bleeding, or warfarin.

Do not stop using Pamelor or Oleptro suddenly, or you could have unpleasant withdrawal symptoms.

What Are Possible Side Effects of Pamelor?

Common side effects of Pamelor include:

  • fast heart rate,
  • blurred vision,
  • urinary retention,
  • dry mouth,
  • constipation,
  • weight gain or loss,
  • dizziness upon standing (orthostatic hypotension),
  • tingly feeling,
  • weakness,
  • lack of coordination,
  • unpleasant taste,
  • nausea,
  • ringing in your ears,
  • breast swelling (in men or women),
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm.

What Are Possible Side Effects of Oleptro?

Common side effects of Oleptro include:

  • drowsiness,
  • sedation,
  • dizziness,
  • lightheadedness,
  • constipation,
  • headache,
  • blurred vision,
  • nausea,
  • vomiting,
  • dry mouth, or
  • change in sexual interest/ability.

Tell your doctor if you have serious side effects of Oleptro including:

  • extreme mood swings,
  • restlessness,
  • sleep problems,
  • dizziness,
  • fainting,
  • fast or pounding heartbeat,
  • easy bruising or bleeding,
  • agitation,
  • hallucinations,
  • fast heart rate,
  • overactive reflexes,
  • diarrhea,
  • loss of coordination,
  • very stiff (rigid) muscles,
  • high fever,
  • confusion,
  • fast or uneven heartbeats,
  • tremors,
  • trouble concentrating,
  • memory problems,
  • weakness,
  • loss of appetite,
  • unsteadiness,
  • seizures,
  • shallow breathing or breathing that stops,
  • chest pain or heavy feeling,
  • pain spreading to the arm or shoulder,
  • nausea,
  • sweating, or
  • general ill feeling (malaise).

What Is Pamelor?

Pamelor (nortriptyline HCl) is an antidepressant that is used to treat mental/mood problems such as depression.

What Is Oleptro?

Oleptro (trazodone hydrochloride extended-release tablets) is a triazolopyridine antidepressant used to treat major depressive disorder (MDD) in adults.

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What Drugs Interact With Pamelor?

Pamelor may interact with narcotic pain medicines.

Pamelor may also interact with other drugs that make you sleepy or slow your breathing (sleeping pills, muscle relaxers, or medicines for anxiety, depression, or seizures), bupropion, cimetidine, reserpine, St. John's wort, terbinafine, other antidepressant or medication to treat mental illness, bladder or urinary medicines, bronchodilators, cold or allergy medicines that contain an antihistamine, medications for Parkinson's disease; medications to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome; decongestants, diet pills, stimulants, or heart rhythm medications.

Do not stop using Pamelor suddenly, or you could have unpleasant withdrawal symptoms.

What Drugs Interact With Oleptro?

Oleptro may interact with monoamine oxidase inhibitors (MAOIs), alcohol, barbiturates, other CNS depressants, ritonavir, ketoconazole, indinavir, itraconazole, carbamazepine, digoxin, phenytoin, serotonergic drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, other drugs affecting coagulation or bleeding, or warfarin. Tell your doctor all medications you use. During pregnancy, Oleptro should be used only if prescribed. This medication may be passed in breast milk. Consult your doctor before breastfeeding.

How Should Pamelor Be Taken?

Pamelor is administered orally in the form of capsules or liquid. Lower than usual dosages are recommended for elderly patients and adolescents.

How Should Oleptro Be Taken?

The recommended starting dose of Oleptro is 150 mg once daily in adults. The dose may be increased by 75 mg/day every three days (i.e., start 225 mg on Day 4 of therapy). The maximum daily dose should not exceed 375 mg.

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References

Pfizer. Lyrica Prescribing Information.
https://www.lyrica.com/
FDA. Oleptro Product Information
https://www.fda.gov/downloads/drugs/drugsafety/ucm202202.pdf

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