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Last reviewed on RxList: 2/13/2017
Pandel Side Effects Center

Last reviewed on RxList 02/10/2017

Pandel (hydrocortisone probutate cream) is a corticosteroid cream used to treat skin inflammations such as allergic reactions, eczema, or psoriasis. Pandel is available in generic form. Common side effects of Pandel include:

  • application site reactions (stinging, burning, irritation, dryness, redness, or peeling)
  • thinning of your skin
  • blistering skin, or
  • stretch marks
Rarely, Pandel may be absorbed into the bloodstream. Tell your doctor if you have side effects of Pandel including:
  • unusual or extreme tiredness,
  • weight loss,
  • headache,
  • swelling ankles or feet,
  • increased thirst or urination, or
  • vision problems.

Apply Pandel to the affected area as a thin film 2 to 4 times daily, or as directed by your doctor. It is not likely other drugs you take orally or inject will have an effect on topically applied hydrocortisone, but many drugs can interact with each other. Tell your doctor all medications and supplements you take. If you are pregnant, only take Pandel if the potential benefit outweighs the potential risk to the fetus. It is not known whether Pandel passes into breast milk. Consult your doctor before breastfeeding.

Our Pandel (hydrocortisone probutate cream) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pandel Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using hydrocortisone topical and call your doctor at once if you have any of these serious side effects:

  • blurred vision, or seeing halos around lights;
  • uneven heartbeats;
  • sleep problems (insomnia);
  • weight gain, puffiness in your face; or
  • feeling tired.

Less serious side effects may include:

  • skin redness, burning, itching, or peeling;
  • thinning of your skin;
  • blistering skin; or
  • stretch marks.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pandel (Hydrocortisone Probutate Cream)

Pandel Professional Information


Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The most frequent adverse reactions reported for PANDEL during clinical trials were application site reactions, including burning in 4, stinging in 2, and moderate paresthesia in 1 out of 226 subjects.

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of PANDEL because these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

These adverse reactions are as follows:

Skin and Subcutaneous Tissue Disorders:rash, papulovesicular rash

Application Site Reactions: dryness, erythema, pruritus, allergic contact dermatitis.

The following local adverse reactions are reported with topical corticosteroids, and they may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infections, skin atrophy, striae, and miliaria.

Read the entire FDA prescribing information for Pandel (Hydrocortisone Probutate Cream)

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© Pandel Patient Information is supplied by Cerner Multum, Inc. and Pandel Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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