Last updated on RxList: 6/20/2019
Papaverine Side Effects Center

Last reviewed on RxList 6/20/2019

Papaverine Hydrochloride Sustained Release Capsules is a vasodilator drug that relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily and is used for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. Side effects of Papaverine include:

  • nausea,
  • stomach discomfort,
  • loss of appetite,
  • dizziness,
  • drowsiness,
  • tiredness,
  • headache,
  • skin rash,
  • decreased appetite,
  • diarrhea,
  • constipation,
  • increased sweating,
  • facial flushing (warmth, redness, or tingly feeling),
  • general discomfort or feeling of being unwell (malaise),
  • spinning sensation (vertigo),
  • increased heart rate,
  • slight increase in blood pressure, and
  • irregular heartbeats.

Papaverine hydrochloride is administered intravenously (IV) in doses of 1 to 4 mL is repeated every 3 hours as indicated. In the treatment of cardiac extrasystoles, 2 doses may be given 10 minutes apart. Papaverine hydrochloride injection may interact with levodopa (Larodopa, Atamet, Parcopa, Sinemet). Other drugs may interact with papaverine injection. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Papaverine should be used only if prescribed. It may be harmful to a fetus. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Papaverine hydrochloride injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Papaverine Consumer Information

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • severe headache, blurred vision, fast heart rate, pounding in your neck or ears, anxiety, shortness of breath;
  • extreme drowsiness;
  • vision changes; or
  • pain, swelling, or redness where the medicine was injected.

Common side effects may include:

  • nausea, upset stomach, loss of appetite, constipation, diarrhea;
  • general ill feeling;
  • headache, drowsiness, dizziness or spinning sensation;
  • flushing (warmth, redness, or tingly feeling);
  • skin rash, increased sweating; or
  • tiredness, lack of energy.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Papaverine (Papaverine)


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Papaverine Professional Information


Although occurring rarely, the reported side effects of papaverine include nausea, abdominal distress, anorexia, constipation, malaise, drowsiness, vertigo, sweating, headache, diarrhea, skin rash, flushing of face, increase in heart rate and depth of respiration and slight increase in blood pressure.

Read the entire FDA prescribing information for Papaverine (Papaverine)


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

© Papaverine Patient Information is supplied by Cerner Multum, Inc. and Papaverine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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