Definition of Paraneoplastic pemphigus (PNP)

Paraneoplastic pemphigus (PNP): a rare, often-fatal, autoimmune disease in which a person’s immune system attacks its own tissues causing painful blistering skin and mucous membranes. Paraneoplastic pemphigus is always associated with an underlying cancerous tumor. In a small number of cases, PNP may go away if the underlying cancer is cured.

Another term for paraneoplastic pemphigus is paraneoplastic autoimmune multiorgan syndrome (PAMS).


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Grant J Anhalt, MD, et al. Paraneoplastic pemphigus. UpToDate. Updated: Oct 30, 2019.

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