Last updated on RxList: 07/12/2021
Paricalcitol Patient Information Including Side Effects

Brand Names: Zemplar

Generic Name: paricalcitol (oral/injection)

What is paricalcitol (Zemplar)?

Paricalcitol is a synthetic (man-made) form of vitamin D. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Paricalcitol is used to help maintain healthy levels of parathyroid hormone in people with chronic kidney disease who are on dialysis.

Paricalcitol oral is for use in adults and children at least 10 years old.

Paricalcitol injection is for use in adults and children at least 5 years old.

Paricalcitol may also be used for purposes not listed in this medication guide.

What are the possible side effects of paricalcitol (Zemplar)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast, slow, or pounding heartbeats;
  • fever, flu symptoms, mouth and throat ulcers;
  • new or worsening cough, fever, trouble breathing;
  • a seizure; or
  • high calcium levels--nausea, vomiting, loss of appetite, constipation, increased thirst or urination, confusion, weight loss, tiredness.

You may be more likely to have a broken bone if your parathyroid hormone levels get too low. Talk with your doctor about how to avoid the risk of fractures.

Common side effects may include:

  • nausea, vomiting;
  • swelling in your hands or feet;
  • dizziness or spinning sensation;
  • joint pain; or
  • runny nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about paricalcitol (Zemplar)?

You should not use paricalcitol if you have high levels of calcium or vitamin D in your blood.


The only purpose of the kidneys is to filter blood. See Answer
Paricalcitol Patient Information including How Should I Take

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What should I discuss with my healthcare provider before using paricalcitol (Zemplar)?

You should not use paricalcitol if you are allergic to it, or if you have high levels of vitamin D or calcium in your body.

You should not be treated with paricalcitol injection if you have ever had a severe allergic reaction to it.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

If you breastfeed while receiving paricalcitol injection, watch for signs of hypercalcemia in your baby (such as feeding problems, vomiting, constipation, or seizure).

How should I use paricalcitol (Zemplar)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Paricalcitol is usually given every other day or 3 times per week. Follow your doctor's instructions carefully.

Paricalcitol oral is taken by mouth.

You may take paricalcitol oral with or without food.

Paricalcitol injection is given as an infusion into a vein during dialysis. A healthcare provider will give you this injection.

Tell your caregivers if you feel any burning, pain, or swelling when paricalcitol is injected.

Your blood will need to be tested often. Your doses may be delayed based on the results.

Even if you have no symptoms, tests can help your doctor determine if this medicine is effective.

You may need to follow a special diet while using paricalcitol. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

Store paricalcitol oral at room temperature away from moisture, light, and heat.


Kidney Stones: Symptoms, Causes, and Treatment See Slideshow
Paricalcitol Patient Information including If I Miss a Dose

What happens if I miss a dose (Zemplar)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Because you will receive paricalcitol injection in a clinical setting, you are not likely to miss a dose. Call your doctor for instructions if you miss a hemodialysis appointment.

What happens if I overdose (Zemplar)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using paricalcitol (Zemplar)?

Avoid using any vitamin D or calcium supplements without your doctor's advice.

If you take paricalcitol oral: Ask your doctor before using an antacid, and use only the type your doctor recommends.

Grapefruit may interact with paricalcitol and lead to unwanted side effects. Avoid the use of grapefruit products.

What other drugs will affect paricalcitol (Zemplar)?

Some medicines can make paricalcitol much less effective when taken at the same time. If you take any of the following medicines, take your oral paricalcitol dose 1 hour before or 4 to 6 hours after you take the other medicine:

  • cholestyramine; or
  • mineral oil.

Tell your doctor about all your current medicines. Many drugs can affect paricalcitol, especially:

  • digoxin (digitalis);
  • a diuretic or "water pill";
  • nefazodone;
  • a phosphate binder--ferric citrate, sevelamer, lanthanum carbonate;
  • an antibiotic--clarithromycin, telithromycin;
  • antifungal medicine--itraconazole, ketoconazole; or
  • antiviral medicine to treat HIV/AIDS--indinavir, nelfinavir, ritonavir, saquinavir.

This list is not complete and many other drugs may affect paricalcitol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Zemplar)?

Your pharmacist can provide more information about paricalcitol.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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