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Last reviewed on RxList: 2/22/2017
Parnate Side Effects Center

Last reviewed on RxList 12/21/2016

Parnate (tranylcypromine sulfate) Tablets is a monoamine oxidase inhibitor (MAOI) used the treatment of major depressive episode without melancholia. Parnate should be used in adults who are closely supervised. Parnate is available in generic form. Common side effects of Parnate include:

  • frequent headaches,
  • vision problems,
  • sensitivity to light,
  • restlessness,
  • weakness,
  • drowsiness,
  • nausea,
  • diarrhea,
  • constipation,
  • loss of appetite,
  • stomach pain,
  • chills,
  • numbness or tingly feeling,
  • dry mouth,
  • decreased urination,
  • problems sleeping,
  • blurred vision,
  • ringing in your ears,
  • impotence, or
  • difficulty having an orgasm.

Tell your doctor if you have unlikely but serious side effects of Parnate including:

A serious side effect of Parnate is the occurrence of hypertensive crises that can be fatal.

Parnate dosage (available in 10 mg tablets) should be adjusted to the requirements of the individual patient. If there are no signs of improvement after about 2 weeks, then the dosage may be increased (10 mg per day) at intervals of 1 to 3 weeks and extended to a maximum of 60 mg per day. Inform the doctor about all the other prescription and over-the-counter medications used, including vitamins, minerals, and herbal products; Parnate interacts with many other medications. Tell your doctor if you are pregnant or plan to become pregnant while using Parnate; it is unknown if it will harm a fetus. Parnate can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Parnate (tranylcypromine sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Parnate Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Stop using tranylcypromine and call your doctor at once if you have any of these serious side effects:

  • frequent headaches, vision problems, sensitivity to light;
  • fast or pounding heart beats, tight feeling in your chest or throat;
  • swelling of your ankles or feet;
  • pale skin, easy bruising or bleeding, unusual weakness;
  • nausea, vomiting, dizziness, sweating, stiffness in your neck;
  • confusion, lack of coordination, feeling light-headed, fainting; or
  • tremors, muscle twitches you cannot control.

Less serious side effects may include:

  • feeling restless, weak, or drowsy;
  • nausea, diarrhea or constipation, loss of appetite, stomach pain;
  • chills, numbness or tingly feeling;
  • dry mouth, decreased urination;
  • blurred vision, ringing in your ears; or
  • impotence, difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Parnate (Tranylcypromine)

Parnate Professional Information


Overstimulation which may include increased anxiety, agitation, and manic symptoms is usually evidence of excessive therapeutic action. Dosage should be reduced, or a phenothiazine tranquilizer should be administered concomitantly.

Patients may experience restlessness or insomnia; may notice some weakness, drowsiness, episodes of dizziness or dry mouth; or may report nausea, diarrhea, abdominal pain, or constipation. Most of these effects can be relieved by lowering the dosage or by giving suitable concomitant medication.

Tachycardia, significant anorexia, edema, palpitation, blurred vision, chills, and impotence have each been reported.

Headaches without blood pressure elevation have occurred.

Rare instances of hepatitis, skin rash, and alopecia have been reported.

Impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has been reported.

Tinnitus, muscle spasm, tremors, myoclonic jerks, numbness, paresthesia, urinary retention, and retarded ejaculation have been reported.

Hematologic disorders including anemia, leukopenia, agranulocytosis, and thrombocytopenia have been reported.

Post-Introduction Reports: The following are spontaneously reported adverse events temporally associated with use of PARNATE (tranylcypromine) . No clear relationship between PARNATE (tranylcypromine) and these events has been established. Localized scleroderma, flare-up of cystic acne, ataxia, confusion, disorientation, memory loss, urinary frequency, urinary incontinence, urticaria, fissuring in corner of mouth, akinesia.

Read the entire FDA prescribing information for Parnate (Tranylcypromine)

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