Last updated on RxList: 1/18/2018
Parnate Side Effects Center

Last reviewed on RxList 1/18/2018

Parnate (tranylcypromine sulfate) Tablets is a monoamine oxidase inhibitor (MAOI) used the treatment of major depressive episode without melancholia. Parnate should be used in adults who are closely supervised. Parnate is available in generic form. Common side effects of Parnate include:

  • frequent headaches,
  • vision problems,
  • sensitivity to light,
  • restlessness,
  • weakness,
  • drowsiness,
  • nausea,
  • diarrhea,
  • constipation,
  • loss of appetite,
  • stomach pain,
  • chills,
  • numbness or tingly feeling,
  • dry mouth,
  • decreased urination,
  • problems sleeping,
  • blurred vision,
  • ringing in your ears,
  • impotence, or
  • difficulty having an orgasm.

Tell your doctor if you have unlikely but serious side effects of Parnate including:

A serious side effect of Parnate is the occurrence of hypertensive crises that can be fatal.

Parnate dosage (available in 10 mg tablets) should be adjusted to the requirements of the individual patient. If there are no signs of improvement after about 2 weeks, then the dosage may be increased (10 mg per day) at intervals of 1 to 3 weeks and extended to a maximum of 60 mg per day. Inform the doctor about all the other prescription and over-the-counter medications used, including vitamins, minerals, and herbal products; Parnate interacts with many other medications. Tell your doctor if you are pregnant or plan to become pregnant while using Parnate; it is unknown if it will harm a fetus. Parnate can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Parnate (tranylcypromine sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Parnate Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • dilated pupils, vision problems, sensitivity to light;
  • sudden and severe headache, neck pain or stiffness;
  • numbness or weakness, problems with vision or speech;
  • fast or pounding heartbeats;
  • fever, cold sweat, nausea, vomiting;
  • a light-headed feeling, like you might pass out;
  • a seizure;
  • manic episodes--racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative;
  • high levels of serotonin in the body--agitation, hallucinations, sweating, shivering, muscle stiffness, twitching, loss of coordination, vomiting, diarrhea; or
  • liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes).

Serious side effects may be more likely in older adults.

Common side effects may include:

  • dizziness, drowsiness;
  • constipation;
  • dry mouth, blurred vision;
  • trouble sleeping;
  • headache; or
  • feeling shaky or excited.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Parnate (Tranylcypromine)


Depression is a(n) __________ . See Answer
Parnate Professional Information


The following adverse reactions are described in greater detail in other sections:

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Based on clinical trial data, the most common adverse reactions to tranylcypromine were dry mouth, dizziness, insomnia, sedation, and headache (>30%) and overexcitement, constipation, blurred vision, and tremor (>10%).

The following adverse reactions have been identified in clinical trials or during postapproval use of PARNATE:

Blood and lymphatic system disorders: agranulocytosis, leukopenia, thrombocytopenia, anemia

Endocrine disorders: impaired water excretion compatible with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

Metabolism and nutrition disorders: significant anorexia, weight gain

Psychiatric disorders: excessive stimulation/overexcitement, manic symptoms/hypomania, agitation, insomnia, anxiety, confusion, disorientation, loss of libido

Nervous system disorders: dizziness, restlessness/akathisia, akinesia, ataxia, myoclonic jerks, tremor, hyper-reflexia, muscle spasm, paresthesia, numbness, memory loss, sedation, drowsiness, dysgeusia, headaches (without blood pressure elevation)

Eye disorders: blurred vision, nystagmus

Ear and labyrinth disorders: tinnitus

Cardiac disorders: tachycardia, palpitations

Vascular disorders: hypertensive crisis, hypertension, hypotension (including postural hypotension with syncope)

Gastrointestinal disorders: diarrhea, constipation, nausea, abdominal pain, dry mouth, fissuring in corner of mouth

Hepatobiliary disorders: hepatitis, elevated aminotransferases

Skin and subcutaneous tissue disorders: localized scleroderma, flare-up of cystic acne, urticaria, rash, alopecia, sweating

Renal and urinary disorders: urinary retention, urinary incontinence, urinary frequency

Reproductive system and breast disorders: impotence, delayed ejaculation

General disorders and administration site conditions: edema, chills, weakness, fatigue/lethargy

Read the entire FDA prescribing information for Parnate (Tranylcypromine)

© Parnate Patient Information is supplied by Cerner Multum, Inc. and Parnate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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