How Do PD-1PD-L1 inhibitors Work?

Reviewed on 10/25/2021

HOW DO PD-1/PD-L1 INHIBITORS WORK?

Programmed cell death protein-1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) inhibitors are drugs used for treating various cancers. PD-L1 is a protein that tends to keep our immune responses under control. PD-L1 is mainly found in some types of cancer cells and some healthy cells.

When PD-L1 binds to the protein PD-1 that is found on the T cells of the immune system, it prevents T cells from destroying PD-L1-containing cancer cells. PD-L1 inhibitors bind to PD-L1 protein and obstruct its binding to PD-1, thus allowing the T cells to destroy the cancer cells.

HOW ARE PD-1/PD-L1 INHIBITORS USED?

PD-1/PD-L1 inhibitors are used for treating:

WHAT ARE SIDE EFFECTS OF PD-1/PD-L1 INHIBITORS?

Some of the side effects of PD-1/PD-L1 inhibitors include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

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WHAT ARE NAMES OF PD-1/PD-L1 INHIBITORS?

Generic and brand names of PD-1/PD-L1 inhibitors include:

References
https://reference.medscape.com/drugs/pd-1-pd-l1-inhibitors

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/pd-l1

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