Penicillin G Benzathine-Penicillin G Procaine

Reviewed on 11/7/2022

What Is Penicillin G Benzathine-Penicillin G Procaine and How Does It Work?

Penicillin G Benzathine-Penicillin G Procaine (Rx) is a combination medicine used for streptococcal group A and pneumococcal infections.

What Are Side Effects Associated with Using Penicillin G Benzathine-Penicillin G Procaine?

Common side effects of Penicillin G Benzathine-Penicillin G Procaine include:

  • nausea,
  • vomiting,
  • diarrhea,
  • itching,
  • sweating,
  • allergic reaction,
  • flushing (sudden warmth, redness, or tingly feeling),
  • feeling anxious,
  • nervousness,
  • weakness,
  • tiredness,
  • headache,
  • dizziness,
  • drowsiness,
  • muscle or joint pain, and
  • pain, swelling, or bruising where an injection was given

Serious side effects of Penicillin G Benzathine-Penicillin G Procaine include:

  • hives,
  • difficulty breathing,
  • swelling of the face, lips, tongue, or throat,
  • joint pain,
  • chills,
  • pain, numbness, tingling, burning, or feeling cold,
  • pale or mottled skin,
  • blue-colored lips, fingers, or toes,
  • severe pain, tingling, weakness, or swelling in the lower leg,
  • weakness in your arms or legs,
  • blistering, peeling, discoloration, or painful skin changes, where the medicine was injected,
  • severe stomach pain,
  • diarrhea that is watery or bloody (even if it occurs months after the last dose),
  • lightheadedness,
  • slow heart rate,
  • weak pulse,
  • fainting,
  • slow breathing,
  • pounding heartbeats,
  • fluttering in the chest,
  • confusion,
  • agitation,
  • hallucinations,
  • extreme fear,
  • seizure,
  • warmth, redness, bleeding, a lump, or skin changes where the medicine was injected,
  • easy bruising or bleeding,
  • pale or yellowed skin,
  • dark-colored urine,
  • urination problems,
  • fever,
  • chills,
  • mouth sores,
  • warmth or redness under the skin, and,
  • vaginal itching or discharge

Rare side effects of Penicillin G Benzathine-Penicillin G Procaine include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

SLIDESHOW

Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow

What Are Dosages of Penicillin G Benzathine-Penicillin G Procaine?

Adult and pediatric dosage

Injectable Suspension

  • 600,000 units/600,000 units/2 mL (ie, 1.2 million units/2 mL)
  • 900,000 units/300,000 units/2 mL (ie, 1.2 million units/2 mL)

Streptococcal Group A Infections

Adult dosage

  • 2.4 million units IM x1; divided dosage administration into multiple sites
  • Alternatively, administer 1.2 million units IM on day 1, then repeat the dose on day 3

Pediatric dosage

Bicillin C-R

  • Less than 14 kg: 600,000 units IM x1
  • 14-27 kg: 900,000-1,200,000 units IM x1
  • 27 kg or more: As adults; 2.4 million units IM x1; divided dosage administration into multiple sites; alternatively, administer 1.2 million units IM on day 1, then repeat the dose on day 3

Bicillin C-R 900/300

  • 900 units/300 units IM x1

Pneumococcal Infections

Adult dosage

  • 1.2 million units IM; repeat q2-3 days until the temperature is normal for 48 hr; other penicillin forms (ie, IV) necessary for severe infection

Pediatric dosage

  • Bicillin C-R: 600,000 units IM; repeat every 2-3 days until the temperature is normal for 48 hours; other penicillin forms (ie, IV) necessary for severe infection
  • Bicillin C-R 900/300: 900 units/300 units IM; repeat every 2-3 days until the temperature is normal for 48 hours; other penicillin forms (ie, IV) necessary for severe infection

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Other Drugs Interact with Penicillin G Benzathine-Penicillin G Procaine?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Penicillin G Benzathine-Penicillin G Procaine has severe interactions with no other drugs.
  • Penicillin G Benzathine-Penicillin G Procaine has serious interactions with the following drugs:
  • Penicillin G Benzathine-Penicillin G Procaine has moderate interactions with the following drugs:
  • Penicillin G Benzathine-Penicillin G Procaine has minor interactions with no other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

QUESTION

Bowel regularity means a bowel movement every day. See Answer

What Are Warnings and Precautions for Penicillin G Benzathine-Penicillin G Procaine?

Contraindications

  • Hypersensitivity; serious and occasionally fatal reactions have been reported

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Penicillin G Benzathine-Penicillin G Procaine?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Penicillin G Benzathine-Penicillin G Procaine?”

Cautions

Pregnancy & Lactation

  • May be acceptable during pregnancy
  • Lactation
    • Excreted into breast milk, caution advised
References
https://reference.medscape.com/drug/flarex-fml-fluorometholone-343624

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