Pentam 300 Side Effects Center

Last updated on RxList: 7/25/2022
Pentam 300 Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Pentam 300?

Pentam 300 (pentamidine isethionate for injection) is an anti-protozoal drug is indicated for the treatment of pneumonia due to Pneumocystis carinii.

What Are Side Effects of Pentam 300?

Common side effects of Pentam 300 include:

Pentam 300 may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • wheezing,
  • choking,
  • other breathing problems after using the medication,
  • lightheadedness,
  • fast or uneven heart rate,
  • painful or difficult urination,
  • confusion,
  • hallucination,
  • pain, burning, irritation, or skin changes where the injection was given,
  • worsening symptoms,
  • signs of a new infection,
  • fever,
  • cough,
  • night sweats,
  • pale skin,
  • shortness of breath,
  • easy bruising,
  • unusual bleeding,
  • purple or pinpoint spots under your skin,
  • severe pain in your upper stomach spreading to your back,
  • nausea,
  • vomiting,
  • headache,
  • hunger,
  • weakness,
  • sweating,
  • confusion,
  • irritability,
  • dizziness,
  • feeling jittery,
  • sore throat,
  • burning in your eyes, and
  • skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Pentam 300

The recommended regimen of Pentam 300 for adults and pediatric patients beyond 4 months of age is 4 mg/kg once a day for 14 to 21 days.

What Drugs, Substances, or Supplements Interact with Pentam 300?

Pentam 300 may interact with other nephrotoxic drugs such as aminoglycosides, amphotericin B, cisplatin, foscarnet, or vancomycin.

Pentam 300 During Pregnancy and Breastfeeding

Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Pentam 300; it is unknown how it would affect a fetus. It is unknown if Pentam 300 passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding while using Pentam 300 is not recommended.

Additional Information

Our Pentam 300 (pentamidine isethionate for injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

What is pneumonia? See Answer
Pentam 300 Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • wheezing, choking, or other breathing problems after using this medication with a nebulizer;
  • a light-headed feeling, like you might pass out;
  • fast or uneven heart rate;
  • painful or difficult urination;
  • confusion, hallucinations;
  • pain, burning, irritation, or skin changes where the injection was given;
  • worsening symptoms, or signs of a new infection (fever, cough, trouble breathing, night sweats);
  • a blood cell disorder--pale skin, feeling light-headed or short of breath, easy bruising, unusual bleeding, purple or red pinpoint spots under your skin;
  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, or feeling jittery; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • loss of appetite; or
  • unusual or unpleasant taste in the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pentam 300 (Pentamidine Isethionate for Injection)

SLIDESHOW

How to Prevent the Common Cold See Slideshow
Pentam 300 Professional Information

SIDE EFFECTS

Caution

Fatalities due to severe hypotension, hypoglycemia, acute pancreatitis and cardiac arrhythmias have been reported in patients treated with pentamidine isethionate, both by the IM and IV routes. Nephrotoxic events (increased creatinine, impaired renal function, azotemia, and renal failure) are common with the parenteral administration of pentamidine isethionate. The administration of the drug should, therefore, be limited to the patients in whom Pneumocystis carinii has been demonstrated.

The most frequently reported spontaneous adverse events (1 to 30%) reported in clinical trials, regardless of their relation to pentamidine isethionate therapy were as follows (n=424):

Cardiovascular:
  Hypotension5.0%
Gastrointestinal:
  Anorexia/Nausea5.9%
Hematologic:
  Anemia1.2%
  Leukopenia10.4%
  Thrombocytopenia2.6%
Hepatic:
  Elevated liver function tests8.7%
Metabolic:
  Hypoglycemia5.9%
Neurologic:
  Confusion/hallucinations1.7%
Skin:
  Sterile abscess and/or necrosis,
  pain, or induration at the site of
  IM injection
11.1%
Rash3.3%
Special Senses:
  Bad taste1.7%
Urogenital:
  Azotemia8.5%
  Elevated serum creatinine23.6%
  Elevated blood urea nitrogen6.6%
  Impaired renal function28.8%

Adverse events with a frequency of less than 1% incidence were as follows (No causal relationship to treatment has been established for these adverse events):

Body as a whole:Allergic reaction (i.e. urticaria, itching, rash), anaphylaxis, arthralgia, chills, extrapulmonary pneumocystosis, headache, night sweats, and Stevens-Johnson syndrome.
Cardiovascular:Abnormal ST segment of electrocardiogram, cardiac arrhythmias, cerebrovascular accident, hypertension, palpitations, phlebitis, syncope, tachycardia, vasodilatation, vasculitis and ventricular tachycardia.
Gastrointestinal:Abdominal pain, diarrhea, dry mouth, dyspepsia, hematochezia, hypersalivation, melena, pancreatitis, splenomegaly, and vomiting.
Hematological:Defibrination, eosinophilia, neutropenia, pancytopenia, and prolonged clotting time.
Hepatic:Hepatic dysfunction, hepatitis and hepatomegaly
Metabolic:Hyperglycemia, hyperkalemia, hypocalcemia, and hypomagnesemia.
Neurological:Anxiety, confusion, depression, dizziness, drowsiness, emotional lability, hypesthesia, insomnia, memory loss, neuropathy, nervousness, neuralgia, paranoia, paresthesia, peripheral neuropathy, seizure, tremors, unsteady gait, and vertigo.
Respiratory system:Asthma, bronchitis, bronchospasm, chest congestion, chest tightness, coryza, cyanosis, eosinophilic or interstitial pneumonitis, gagging, hemoptysis, hyperventilation, laryngitis, laryngospasm, non-specific lung disorder, nasal congestion, pleuritis, pneumothorax, rales, rhinitis, shortness of breath, and tachypnea.
Skin:Desquamation, dry and breaking hair, dry skin, erythema, dermatitis, pruritus, rash, and urticaria.
Special senses:Blepharitis, blurred vision, conjunctivitis, contact lens discomfort, eye pain or discomfort, loss of hearing, loss of taste, and loss of smell.
Urogenital:Flank pain, hematuria, incontinence, nephritis, renal dysfunction and renal failure.

From post-marketing clinical experience with pentamidine isethionate, the following adverse events have been reported: cough, diabetes mellitus/ketoacidosis, dyspnea, infiltration (extravasation–see WARNINGS), and torsades de pointes.

Read the entire FDA prescribing information for Pentam 300 (Pentamidine Isethionate for Injection)

© Pentam 300 Patient Information is supplied by Cerner Multum, Inc. and Pentam 300 Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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