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Pepcid

Last reviewed on RxList: 5/14/2020
Pepcid Side Effects Center

What Is Pepcid?

Pepcid (famotidine) is an H2-blocker used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Pepcid is available as a generic drug.

What Are Side Effects of Pepcid?

Side effects of Pepcid are not common, but may include:

Dosage for Pepcid

Pepcid (famotidine) dosage depends on the condition being treated.

What Drugs, Substances, or Supplements Interact with Pepcid?

Pepcid may interact with atazanavir, itraconazole, ketoconazole, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use.

Pepcid During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant during treatment with Pepcid; it is not expected to be harmful to a fetus. Pepcid passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Pepcid (famotidine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Pepcid Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using famotidine and call your doctor at once if you have:

  • confusion, hallucinations, agitation, lack of energy;
  • a seizure;
  • fast or pounding heartbeats, sudden dizziness (like you might pass out); or
  • unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Some side effects may be more likely in older adults and in people who have severe kidney disease.

Common side effects may include:

  • headache;
  • dizziness; or
  • constipation or diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pepcid (Famotidine)

Pepcid Professional Information

SIDE EFFECTS

The adverse reactions listed below have been reported during domestic and international clinical trials in approximately 2500 patients. In those controlled clinical trials in which PEPCID Tablets were compared to placebo, the incidence of adverse experiences in the group which received PEPCID Tablets, 40 mg at bedtime, was similar to that in the placebo group.

The following adverse reactions have been reported to occur in more than 1% of patients on therapy with PEPCID in controlled clinical trials, and may be causally related to the drug: headache (4.7%), dizziness (1.3%), constipation (1.2%) and diarrhea (1.7%).

The following other adverse reactions have been reported infrequently in clinical trials or since the drug was marketed. The relationship to therapy with PEPCID has been unclear in many cases. Within each category the adverse reactions are listed in order of decreasing severity:

Body as a Whole: fever, asthenia, fatigue

Cardiovascular: arrhythmia, AV block, palpitation. Prolonged QT interval, in patients with impaired renal function, has been reported very rarely.

Gastrointestinal: cholestatic jaundice, hepatitis, liver enzyme abnormalities, vomiting, nausea, abdominal discomfort, anorexia, dry mouth

Hematologic: rare cases of agranulocytosis, pancytopenia, leukopenia, thrombocytopenia

Hypersensitivity: anaphylaxis, angioedema, orbital or facial edema, urticaria, rash, conjunctival injection

Musculoskeletal: rhabdomyolysis, musculoskeletal pain including muscle cramps, arthralgia

Nervous System/Psychiatric: grand mal seizure; psychic disturbances, which were reversible in cases for which follow-up was obtained, including hallucinations, confusion, agitation, depression, anxiety, decreased libido; paresthesia; insomnia; somnolence. Convulsions, in patients with impaired renal function, have been reported very rarely.

Respiratory: bronchospasm, interstitial pneumonia

Skin: toxic epidermal necrolysis/Stevens-Johnson syndrome (very rare), alopecia, acne, pruritus, dry skin, flushing

Special Senses: tinnitus, taste disorder

Other: rare cases of impotence and rare cases of gynecomastia have been reported; however, in controlled clinical trials, the incidences were not greater than those seen with placebo.

The adverse reactions reported for PEPCID Tablets may also occur with PEPCID for Oral Suspension.

Pediatric Patients

In a clinical study in 35 pediatric patients < 1 year of age with GERD symptoms [e.g., vomiting (spitting up), irritability (fussing)], agitation was observed in 5 patients on famotidine that resolved when the medication was discontinued.

Read the entire FDA prescribing information for Pepcid (Famotidine)

Related Resources for Pepcid

Read the Pepcid User Reviews »

© Pepcid Patient Information is supplied by Cerner Multum, Inc. and Pepcid Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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