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Pepcid vs. Prilosec

Medical and Pharmacy Editor:

Are Pepcid and Prilosec the Same Thing?

Pepcid (famotidine) and Prilosec (omeprazole) are used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.

Pepcid and Prilosec belong to different drug classes. Pepcid (famotidine) is an H2-blocker and Prilosec is a proton pump inhibitor (PPI).

Pepcid and Prilosec are available over-the-counter (OTC) and in generic form.

What Are Possible Side Effects of Pepcid?

Common side effects of Pepcid include:

  • constipation,
  • diarrhea,
  • fatigue,
  • dizziness,
  • weakness,
  • mood changes,
  • headache,
  • insomnia,
  • muscle pain or cramps,
  • joint pain,
  • dry mouth,
  • nausea, or
  • vomiting.

What Are Possible Side Effects of Prilosec?

Common side effects of Prilosec include:

  • headache,
  • nausea,
  • vomiting,
  • diarrhea,
  • stomach pain,
  • gas,
  • constipation,
  • fever, or
  • cold symptoms (stuffy nose, sneezing, and sore throat).

What is Pepcid?

Pepcid (famotidine) is an H2-blocker used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Pepcid is available as a generic drug.

What is Prilosec?

Prilosec (omeprazole) is a proton pump inhibitor (PPI) used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, which are all caused by stomach acid.

What Drugs Interact With Pepcid?

Pepcid may interact with atazanavir, itraconazole, ketoconazole, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use.

What Drugs Interact With Prilosec?

Prilosec may interact with digoxin, diuretics (water pills), blood thinners, antifungal medications such as ketoconazole, antibiotics such as ampicillin, iron, or methotrexate, and HIV or AIDS medications such as atazanavir and nelfinavir.

Prilosec may also interact with bosentan, cilostazol, clopidogrel, cyclosporine, diazepam, disulfiram, St. John's wort, tacrolimus, or seizure medications.

How Should Pepcid Be Taken?

Pepcid (famotidine) dosage depends on the condition being treated.

How Should Prilosec Be Taken?

The recommended adult oral dose of Prilosec ranges from 20 mg to 60 mg once daily, depending on the condition being treated. For maximal efficacy, Prilosec tablets should be taken before meals, swallowed whole and should not be crushed, chewed or opened.

Reviewed on 8/8/2018


SOURCE:
McNeil Consumer Pharmaceuticals Co. Pepcid Consumer Information.
www.pepcid.com
Procter & Gamble. Priolsec Consumer Product Information.
https://www.prilosecotc.com/en-us

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