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Last reviewed on RxList: 8/12/2010
Percodan Side Effects Center

Last reviewed on RxList 01/31/2017

Percodan (aspirin and oxycodone hydrochloride) is a combination of a salicylate and a narcotic pain reliever used to relieve moderate to severe pain. Percodan is available in generic form. Common side effects of Percodan include:

Tell your doctor if you have serious side effects of Percodan including:

  • slow/fast/irregular heartbeat,
  • mental/mood changes (such as depression, hallucinations, confusion),
  • difficult or painful urination,
  • ringing in the ears,
  • decreased hearing,
  • vision changes,
  • easy bruising or bleeding,
  • stomach or abdominal pain,
  • black stools,
  • vomit that looks like coffee grounds,
  • yellowing eyes or skin,
  • dark urine,
  • persistent tiredness,
  • persistent nausea, or
  • changes in the amount of urine.

The usual dosage of Percodan is one tablet every 6 hours as needed for pain. The maximum daily dose of aspirin should not exceed 4 grams or 12 tablets. Percodan may interact with antidepressants, other medicines that make you sleepy or could slow your breathing (such as cold or allergy medicines, sedatives, narcotic pain medicines, sleeping pills, muscle relaxers, and medicines for seizures, depression, or anxiety), bupropion, deferasirox, leflunomide, methotrexate, sirolimus, tacrolimus, tenofovir, antiviral medicines, aspirin or other salicylates, bowel cleansing preparations, glaucoma medications, or medications used to prevent blood clots. Tell your doctor all medications and supplements you are taking. Percodan is not recommended for use during pregnancy. Do not use this medication during the last 3 months of pregnancy because of possible harm to the fetus or problems during delivery. Infants born to mothers who have used oxycodone may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. Tell your doctor if you notice these symptoms in your newborn. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended. The oxycodone in Percodan is a narcotic, and may be habit-forming. Do not abruptly stop taking this medication or you may have withdrawal symptoms.

Our Percodan (aspirin and oxycodone hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Percodan Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe stomach pain or constipation, vomiting;
  • black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • weak or shallow breathing, fast or slow heartbeats;
  • confusion, hallucinations, feeling like you might pass out;
  • easy bruising or bleeding;
  • seizures; or
  • decreased hearing, ringing in your ears.

Less serious side effects may include:

  • headache, dizziness, drowsiness;
  • constipation, heartburn, upset stomach, bloating, gas, diarrhea; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Percodan (Aspirin and Oxycodone Hydrochloride)

Percodan Professional Information


Serious adverse reactions that may be associated with PERCODAN (aspirin and oxycodone hydrochloride) tablet use include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock (see OVERDOSE).

The most frequently observed non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation and pruritus.

Aspirin may increase the likelihood of hemorrhage due to its effect on the gastric mucosa and platelet function. Furthermore, aspirin has the potential to cause anaphylaxis in hypersensitive patients as well as angioedema especially in patients with chronic urticaria. Other adverse reactions due to aspirin use include anorexia, reversible hepatotoxicity, leukopenia, thrombocytopenia, purpura, decreased plasma iron concentration, and shortened erythrocyte survival time.

Other adverse reactions obtained from postmarketing experiences with PERCODAN (aspirin and oxycodone hydrochloride) tablets are listed by organ system and in decreasing order of severity and/or frequency as follows:

Body as a Whole

allergic reaction, malaise, asthenia, headache, anaphylaxis, fever, hypothermia, thirst, increased sweating, accident, accidental overdose, non-accidental overdose.


tachycardia, dysrhythmias, hypotension, orthostatic hypotension, bradycardia, palpitations

Central and Peripheral Nervous System

stupor, paresthesia, agitation, cerebral edema, coma, confusion, dizziness, headache, subdural or intracranial hemorrhage, lethargy, seizures, anxiety, mental impairment

Fluid and Electrolyte

dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis


hemorrhagic gastric/duodenal ulcer, gastric/peptic ulcer, dyspepsia, abdominal pain, diarrhea, eructation, dry mouth, gastrointestinal bleeding, intestinal perforation, nausea, vomiting, transient elevations of hepatic enzymes, hepatitis, Reye syndrome, pancreatitis, intestinal obstruction, ileus

Hearing and Vestibular

hearing loss, tinnitus. Patients with high frequency loss may have difficulty perceiving tinnitus. In these patients, tinnitus cannot be used as a clinical indicator of salicylism.


unspecified hemorrhage, purpura, reticulocytosis, prolongation of prothrombin time, disseminated intravascular coagulation, ecchymosis, thrombocytopenia


acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria, anaphylactoid reaction

Metabolic and Nutritional

hypoglycemia, hyperglycemia, acidosis, alkalosis




miosis, visual disturbances, red eye


drug dependence, drug abuse, somnolence, depression, nervousness, hallucination


prolonged pregnancy and labor, stillbirths, lower birth weight infants, antepartum and postpartum bleeding, closure of patent ductus arteriosis

Respiratory System

bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, aspiration, hypoventilation, laryngeal edema

Skin and Appendages

urticaria, rash, flushing


interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure, urinary retention

Read the entire FDA prescribing information for Percodan (Aspirin and Oxycodone Hydrochloride)

Related Resources for Percodan

Read the Percodan User Reviews »

© Percodan Patient Information is supplied by Cerner Multum, Inc. and Percodan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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