Periostat

Last updated on RxList: 1/25/2017
Periostat Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 02/17/2017

Periostat (doxycycline hyclate) is a tetracycline antibiotic indicated for use as an adjunct to dental procedures including scaling and root planning to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis. Side effects of Periostat include:

Tell your doctor if you have serious side effects of Periostat including:

  • sunburn (sun sensitivity),
  • painful or difficult swallowing, or
  • a change in the amount of urine.

Periostat dosage differs from that of doxycycline used to treat infections. Exceeding the recommended dosage may result in an increased incidence of side effects including the development of resistant microorganisms. Periostat is taken orally in capsule form. Tell your doctor if you become pregnant while taking Periostat. Periostat may interact with cholesterol-lowering medications, isotretinoin, tretinoin, antacids, products containing bismuth subsalicylate (such as Pepto-Bismol), minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements, blood thinners, or penicillin antibiotics. Tell your doctor all medications and supplements you use. Results from animal studies indicate that doxycycline crosses the placenta and is found in fetal tissues. The use of Periostat may cause discoloration of the teeth in the fetus when administered in the last half of pregnancy and may discolor the teeth when taken as an infant or child up to age 8 years. Talk to your doctor about using birth control while taking Periostat. Periostat passes into breast milk and may affect bone and tooth development in a nursing baby. Breastfeeding while taking Periostat is not recommended.

Our Periostat (doxycycline hyclate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Mouth Problems: TMJ, Canker Sores, Painful Gums and More See Slideshow
Periostat Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using doxycycline.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • throat irritation, trouble swallowing;
  • chest pain, irregular heart rhythm, feeling short of breath;
  • little or no urination;
  • low white blood cell counts--fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea, vomiting, upset stomach, loss of appetite;
  • mild diarrhea;
  • skin rash or itching;
  • darkened skin color; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Periostat (Doxycycline Hyclate)

QUESTION

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Periostat Professional Information

SIDE EFFECTS

Adverse Reactions in Clinical Trials of a bioequivalent form of doxycycline hyclate capsules: In clinical trials of adult patients with periodontal disease 213 patients received 20 mg BID over a 9 - 12 month period. The most frequent adverse reactions occurring in studies involving treatment with a bioequivalent form of doxycycline hyclate capsules or placebo are listed below:

Incidence (%) of Adverse Reactions in Clinical Trials of Doxycycline Hyclate Capsules, 20mg (Bioequivalent to Doxycycline Hyclate Tablets, 20mg) vs. Placebo

Adverse Reaction Doxycycline Hyclate
Capsules 20 mg BID
(n=213)
Placebo
(n=215)
Headache 55 (26%) 56 (26%)
Common Cold 47 (22%) 46 (21%)
Flu Symptoms 24 (11%) 40 (19%)
Tooth Ache 14 (7%) 28 (13%)
Periodontal Abscess 8 (4%) 21 (10%)
Tooth Disorder 13 (6%) 19 (9%)
Nausea 17 (8%) 12 (6%)
Sinusitis 7 (3%) 18 (8%)
Injury 11 (5%) 18 (8%)
Dyspepsia 13 (6%) 5 (2%)
Sore Throat 11 (5%) 13 (6%)
Joint Pain 12 (6%) 8 (4%)
Diarrhea 12 (6%) 8 (4%)
Sinus Congestion 11 (5%) 11 (5%)
Coughing 9 (4%) 11 (5%)
Sinus Headache 8 (4%) 8 (4%)
Rash 8 (4%) 6 (3%)
Back Pain 7 (3%) 8 (4%)
Back Ache 4 (2%) 9 (4%)
Menstrual Cramp 9 (4%) 5 (2%)
Acid Indigestion 8 (4%) 7 (3%)
Pain 8 (4%) 5 (2%)
Infection 4 (2%) 6 (3%)
Gum Pain 1 (<1%) 6 (3%)
Bronchitis 7 (3%) 5 (2%)
Muscle Pain 2 (1%) 6 (3%)

Note: Percentages are based on total number of study participants in each treatment group.

Adverse Reactions for Tetracyclines: The following adverse reactions have been observed in patients receiving tetracyclines:

Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with vaginal candidiasis) in the anogenital region. Hepatotoxicity has been reported rarely. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving the capsule forms of the drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION Section).

Skin: maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS Section).

Renal toxicity: Rise in BUN has been reported and is apparently dose related. (See WARNINGS Section).

Hypersensitivity reactions: urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported.

Read the entire FDA prescribing information for Periostat (Doxycycline Hyclate)

© Periostat Patient Information is supplied by Cerner Multum, Inc. and Periostat Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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