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Last reviewed on RxList: 7/24/2017
Persantine Side Effects Center

Last reviewed on RxList 7/24/2017

Persantine (dipyridamole) is a platelet inhibitor used to prevent blood clots after heart valve replacement surgery. Persantine is available in generic form. Common side effects of Persantine include:

  • dizziness,
  • stomach upset,
  • diarrhea,
  • vomiting,
  • headache, and
  • flushing (warmth, redness, or tingly feeling under your skin), particularly at first as your body adjusts to the medication.

Other side effects of Persantine include:

  • muscle or joint pain,
  • headache, or
  • skin rash or itching.

Tell your doctor if you have serious side effects of Persantine including:

  • fainting,
  • stomach pain,
  • yellowing eyes or skin,
  • dark urine, or
  • unusual bleeding or bruising.

The recommended dose of Persantine is 75-100 mg four times daily as an adjunct to the usual warfarin therapy. Persantine may interact with nonsteroidal anti-inflammatory drugs (NSAIDs) or other blood thinners such as warfarin (Coumadin). Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. During pregnancy, Persantine should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.

Our Persantine (dipyridamole USP) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Persantine Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • nosebleed or other bleeding that will not stop;
  • black, bloody, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • dizziness;
  • upset stomach, diarrhea, vomiting;
  • warmth, redness, or tingly feeling under your skin;
  • muscle or joint pain;
  • headache; or
  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Persantine (Dipyridamole)

Persantine Professional Information


Adverse reactions at therapeutic doses are usually minimal and transient. On long-term use of Persantine (dipyridamole USP) tablets initial side effects usually disappear. The following reactions in Table 1 were reported in two heart valve replacement trials comparing Persantine (dipyridamole) E tablets and warfarin therapy to either warfarin alone or warfarin and placebo:

Table 1: Adverse Reactions Reported in 2 Heart Valve Replacement Trials

Adverse Reaction PERSANTINE
Tablets / Warfarin Placebo/ Warfarin
Number of patients 147 170
Dizziness 13.6% 8.2%
Abdominal distress 6.1% 3.5%
Headache 2.3% 0.0%
Rash 2.3% 1.1%

Other reactions from uncontrolled studies include diarrhea, vomiting, flushing and pruritus. In addition, angina pectoris has been reported rarely and there have been rare reports of liver dysfunction. On those uncommon occasions when adverse reactions have been persistent or intolerable, they have ceased on withdrawal of the medication.

When Persantine (dipyridamole) tablets were administered concomitantly with warfarin, bleeding was no greater in frequency or severity than that observed when warfarin was administered alone. In rare cases, increased bleeding during or after surgery has been observed.

In post-marketing reporting experience, there have been rare reports of hypersensitivity reactions (such as rash, urticaria, severe bronchospasm, and angioedema), larynx edema, fatigue, malaise, myalgia, arthritis, nausea, dyspepsia, paresthesia, hepatitis, thrombocytopenia, alopecia, cholelithiasis, hypotension, palpitation, and tachycardia.

Read the entire FDA prescribing information for Persantine (Dipyridamole)

Related Resources for Persantine

Read the Persantine User Reviews »

© Persantine Patient Information is supplied by Cerner Multum, Inc. and Persantine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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