Pexeva vs. Prozac

Are Pexeva and Prozac the Same Thing?

Pexeva (paroxetine mesylate) and Prozac (fluoxetine) are selective serotonin reuptake inhibitor (SSRI) antidepressants used to treat depression, obsessive-compulsive disorder, and premenstrual dysphoric disorder (PMDD).

Pexeva is also used to treat anxiety disorders and post-traumatic stress disorder (PTSD).

Prozac is also used to treat bulimia and panic disorder.

Side effects of Pexeva and Prozac that are similar include nausea, drowsiness, dizziness, trouble sleeping (insomnia), changes in appetite, dry mouth, headache, nervousness, constipation, weight changes, decreased sex drive, impotence, and difficulty having an orgasm.

Side effects of Pexeva that are different from Prozac include weakness, sweating, blurred vision, yawning, restlessness, and ringing in your ears.

Side effects of Prozac that are different from Pexeva include upset stomach, anxiety, heart palpitations, and cold symptoms (stuffy nose, sneezing, sore throat).

Both Pexeva and Prozac may interact with nonsteroidal anti-inflammatory drugs (NSAIDs), other drugs that can make you sleepy (cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, medicines for seizures or anxiety), other antidepressants, blood thinners, St. John's wort, tryptophan, medicines to treat psychiatric disorders, and “triptans” for migraine.

Pexeva may also interact with cimetidine, fentanyl, fosamprenavir, linezolid, ritonavir, tamoxifen, theophylline, tramadol, and heart medications.

Prozac may also interact with alcohol and medicines to treat ADHD or narcolepsy.

Withdrawal symptoms may occur if you suddenly stop taking Pexeva or Prozac.

What Are Possible Side Effects of Pexeva?

Common side effects of Pexeva include:

  • nausea,
  • drowsiness,
  • dizziness,
  • trouble sleeping (insomnia),
  • loss of appetite,
  • weakness,
  • dry mouth,
  • sweating,
  • blurred vision,
  • yawning,
  • headache,
  • restlessness,
  • nervousness,
  • constipation,
  • weight changes,
  • decreased sex drive,
  • impotence,
  • difficulty having an orgasm, or
  • ringing in your ears.

Report any worsening depression or suicidal thoughts you may have while taking Pexeva to your doctor. Tell your doctor if you have serious side effects of Pexeva including:

  • shakiness (tremor),
  • inability to keep still,
  • numbness or tingling,
  • easy bruising or bleeding,
  • fast or irregular heartbeat,
  • muscle weakness or spasm, or
  • seizures.

What Are Possible Side Effects of Prozac?

Common side effects of Prozac include:

  • nausea,
  • upset stomach,
  • constipation,
  • headaches,
  • anxiety,
  • sleep problems (insomnia),
  • drowsiness,
  • dizziness,
  • nervousness,
  • heart palpitations,
  • loss of appetite or increase in appetite,
  • weight changes,
  • cold symptoms (stuffy nose, sneezing, sore throat),
  • dry mouth,
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm.

What Is Pexeva?

Pexeva (paroxetine mesylate) is a selective serotonin reuptake inhibitor (SSRI) type of antidepressant used to treat depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

What Is Prozac?

Prozac is a prescription medicine used to treat depression. It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider.

Prozac is used to treat:

  • Major Depressive Disorder (MDD)
  • Obsessive Compulsive Disorder (OCD)
  • Bulimia Nervosa*
  • Panic Disorder*
  • Depressive episodes associated with Bipolar I Disorder, taken with olanzapine (Zyprexa)
  • Treatment Resistant Depression (depression that has not gotten better with atleast 2 other treatments), taken with olanzapine (Zyprexa)*

*Not approved for use in children

Talk to your healthcare provider if you do not think that your condition is getting betterwith Prozac treatment.

SLIDESHOW

Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow

What Drugs Interact With Pexeva?

Pexeva may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures or anxiety, nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, cimetidine, fentanyl, fosamprenavir, linezolid, ritonavir, St. John's wort, tamoxifen, theophylline, tramadol, tryptophan, heart medications, other antidepressants, medicine to treat psychiatric disorders, almotriptan, frovatriptan, sumatriptan, naratripta, rizatriptan, or zolmitriptan. Tell your doctor all medications and supplements you use. Pexeva is not recommended for use during pregnancy. It may harm a fetus. Babies born to mothers who have used this drug during the last 3 months of pregnancy may develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice symptoms in your newborn, tell the doctor. Since untreated depression can be a serious condition, do not stop taking this medication unless directed by your doctor. This drug passes into breast milk. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

What Drugs Interact With Prozac?

Prozac may interact with cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, medicine for seizures or anxiety, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), other antidepressants, blood thinners, or migraine headache medicines.

Prozac may also interact with alprazolam, clopidogrel, clozapine, flecainide, haloperidol, nebivolol, vinblastine, or seizure medications.

Withdrawal symptoms may occur if you suddenly stop taking Prozac.

How Should Pexeva Be Taken?

The recommended initial dose of Pexeva is 20 mg/day.

How Should Prozac Be Taken?

Take Prozac exactly as prescribed. Your healthcare provider may need to change the dose of Prozac until it is the right dose for you.

Prozac may be taken with or without food.

If you miss a dose of Prozac, take the missed dose as soon as you remember.If it is almost time for the next dose, skip the missed dose and take your nextdose at the regular time. Do not take two doses of Prozac at the same time.

If you take too much Prozac, call your healthcare provider or poison controlcenter right away, or get emergency treatment.

QUESTION

Depression is a(n) __________ . See Answer
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References
FDA. Pexeva Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021299s033lbl.pdf

Lilly. Prozac Product Information.

http://pi.lilly.com/us/prozac.pdf

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