Pfizer COVID Vaccine vs. Moderna COVID Vaccine

Reviewed on 1/6/2021

Are the Pfizer COVID Vaccine and the Moderna COVID Vaccine the Same Thing?

The Pfizer-BioNTech COVID Vaccine and the Moderna COVID-19 Vaccine are unapproved vaccines that may prevent COVID-19. There is no FDA-approved vaccine to prevent COVID-19.

Both the Pfizer-BioNTech COVID Vaccine and the Moderna COVID-19 Vaccine use mRNA technology.

The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved products, Pfizer-BioNTech COVID-19 Vaccine and Moderna COVID-19 Vaccine, for active immunization to prevent COVID-19 in individuals 18 years of age and older.

Both the Pfizer-BioNTech COVID Vaccine and the Moderna COVID-19 Vaccine require 2 doses administered intramuscularly. A difference is that the Pfizer-BioNTech COVID-19 Vaccine us a series of two doses (0.3 mL each) 3 weeks apart while the Moderna COVID-19 Vaccine is administered as a series of two doses (0.5 mL each) 1 month apart.

Side effects of Pfizer-BioNTech COVID Vaccine and Moderna COVID-19 Vaccine that are similar include injection site reactions (pain, tenderness, swelling, redness), tiredness/fatigue, headache, muscle pain, chills, joint pain, fever, nausea, feeling unwell (malaise), and swollen lymph nodes (lymphadenopathy), and rarely, severe allergic reaction that usually occurs within a few minutes to one hour after getting a dose of the Pfizer-BioNTech COVID-19 Vaccine or the Moderna COVID-19 Vaccine.

There is no information on the use of the Pfizer-BioNTech COVID-19 Vaccine or the Moderna COVID-19 Vaccine with other vaccines.

What Are Possible Side Effects of the Pfizer COVID Vaccine?

Side effects of the Pfizer-BioNTech COVID-19 Vaccine include:

  • injection site reactions (pain, swelling, redness),
  • fatigue,
  • headache,
  • muscle pain,
  • chills,
  • joint pain,
  • fever,
  • nausea,
  • feeling unwell (malaise), and
  • swollen lymph nodes (lymphadenopathy)

What Are Possible Side Effects of the Moderna COVID Vaccine?

Side effects of the Moderna COVID-19 Vaccine include:

  • injection site reactions (pain, swelling, redness),
  • fatigue,
  • headache,
  • muscle pain,
  • chills,
  • joint pain,
  • fever,
  • nausea,
  • vomiting, and
  • swollen lymph nodes in the armpits (lymphadenopathy)

Additional adverse reactions, some of which may be serious, may become apparent with more widespread use of the Moderna COVID-19 Vaccine.

What Is the Pfizer COVID Vaccine?

The Pfizer-BioNTech COVID-19 Vaccine is an unapproved vaccine that may prevent COVID-19. There is no FDA-approved vaccine to prevent COVID-19.

What Is the Moderna COVID Vaccine?

The Moderna COVID-19 Vaccine is an unapproved vaccine that may prevent COVID-19. There is no FDA-approved vaccine to prevent COVID-19.

The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved product Moderna COVID-19 Vaccine for active immunization to prevent COVID-19 in individuals 18 years of age and older.

What Drugs Interact with the Pfizer COVID Vaccine?

The Pfizer-BioNTech COVID-19 Vaccine may interact with other medicines.

Tell your doctor all medications and supplements you use and all other vaccines you recently received.

What Drugs Interact with the Moderna COVID Vaccine?

The Moderna COVID-19 Vaccine may interact with other medicines.

Tell your doctor all medications and supplements you use and all other vaccines you recently received.

How Should the Pfizer COVID Vaccine be Taken?

The Pfizer-BioNTech COVID-19 Vaccine is a suspension for intramuscular injection administered as a series of two doses (0.3 mL each) 3 weeks apart.

How Should the Moderna COVID Vaccine be Taken?

The Moderna COVID-19 Vaccine is a suspension for intramuscular injection administered as a series of two doses (0.5 mL each) 1 month apart.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Pfizer. Biontech COVID-19 Vaccine Product Information

https://30g7el1b4b1n28kgpr414nuu-wpengine.netdna-ssl.com/wp-content/uploads/2020/12/Pfizer-BioNTech-COVID-19-Vaccine-EUA-Fact-Sheet-for-HCP_0.pdf

FDA. Moderna COVID-19 Vaccine Product Information.

https://www.fda.gov/media/144637/download

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