Phenergan-Codeine

Last updated on RxList: 3/29/2021
Phenergan-Codeine Side Effects Center

What Is Phenergan-Codeine?

Phenergan-Codeine (codeine and promethazine) is a combination of a narcotic that acts a pain reliever and a cough suppressant, and an antihistamine, used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. The brand name Phenergan-Codeine is no longer available in the U.S. Generic versions may be available.

What Are Side Effects of Phenergan-Codeine?

Common side effects of Phenergan-Codeine (codeine and promethazine) include:

  • drowsiness,
  • dizziness,
  • sleepiness,
  • headache,
  • lightheadedness,
  • restlessness,
  • nervousness,
  • anxiety,
  • blurred vision,
  • ringing in your ears,
  • upset stomach,
  • nausea,
  • vomiting,
  • constipation,
  • sleep problems (insomnia),
  • increased sweating,
  • dry mouth,
  • skin rash, or
  • flushing (warmth, redness, or tingly feeling under your skin).

Tell your doctor if you have unlikely but serious side effects of Phenergan-Codeine including:

Dosage for Phenergan-Codeine

The adult dose of codeine and promethazine is 1 tsp (5 ml) every 4 to 6 hours, not to exceed 30 ml in 24 hours. Pediatric dose is based on the child's weight.

What Drugs, Substances, or Supplements Interact with Phenergan-Codeine?

Codeine and promethazine may interact with sedatives or anxiety medicines, antidepressants, narcotics, phenobarbital, amobarbital, secobarbital, MAO inhibitors, atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, methscopolamine, and scopolamine. Tell your doctor all medications you use.

Phenergan-Codeine During Pregnancy and Breastfeeding

During pregnancy, this drug should be used only if prescribed. It is not recommended for use during the last 3 months of pregnancy due to increased risk for withdrawal symptoms such as irritability, abnormal/persistent crying, diarrhea, or seizures. Tell your doctor if you notice symptoms in your newborn. This product passes into breast milk and may rarely have undesirable effects on a nursing infant. Tell your doctor if your infant develops increased sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breastfeeding. The codeine in this medication may be habit-forming. Withdrawal symptoms may occur if you suddenly stop taking this drug.

Additional Information

Our Phenergan-Codeine (codeine and promethazine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Allergies can best be described as: See Answer
Phenergan-Codeine Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using this medicine and call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing;
  • extreme drowsiness, confusion, feeling weak or limp;
  • uncontrolled muscle movements in your face, neck, arms, or legs;
  • a light-headed feeling, like you might pass out;
  • a seizure;
  • adrenal gland problems--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

  • dry mouth, nausea, vomiting, constipation;
  • confusion, dizziness, headache;
  • drowsiness, lack of energy;
  • tremors, coordination problems;
  • feeling anxious, restless, nervous, or irritable;
  • urination problems;
  • sweating; or
  • shortness of breath.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Phenergan-Codeine (Codeine Phosphate and Promethazine HCl)

SLIDESHOW

Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Phenergan-Codeine Professional Information

SIDE EFFECTS

Codeine

Central Nervous System

CNS depression, particularly respiratory depression, and to a lesser extent circulatory depression; light-headedness, dizziness, sedation, euphoria, dysphoria, headache, transient hallucination, disorientation, visual disturbances, and convulsions.

Cardiovascular

Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension (common to narcotic analgesics).

Gastrointestinal

Nausea, vomiting, constipation, and biliary tract spasm. Patients with chronic ulcerative colitis may experience increased colonic motility; in patients with acute ulcerative colitis, toxic dilation has been reported.

Genitourinary

Oliguria, urinary retention, antidiuretic effect has been reported (common to narcotic analgesics).

Allergic

Infrequent pruritus, giant urticaria, angioneurotic edema, and laryngeal edema.

Other

Flushing of the face, sweating and pruritus (due to opiate-induced histamine release); weakness.

Promethazine

Central Nervous System

Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness, confusion, disorientation and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular

Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic

Dermatitis, photosensitivity, urticaria.

Hematologic

Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal

Dry mouth, nausea, vomiting, jaundice.

Respiratory

Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal) (see WARNINGSPromethazine; Respiratory Depression).

Other

Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported (see WARNINGSPromethazine; Neuroleptic Malignant Syndrome).

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium and agitated behavior have also been reported in some of these patients.

Drug Abuse And Dependence

Controlled Substance

Promethazine HCl and Codeine Phosphate Oral Solution is a Schedule V Controlled Substance.

Abuse

Codeine is known to be subject to abuse; however, the abuse potential of oral codeine appears to be quite low. Even parenteral codeine does not appear to offer the psychic effects sought by addicts to the same degree as heroin or morphine. However, codeine must be administered only under close supervision to patients with a history of drug abuse or dependence.

Dependence

Psychological dependence, physical dependence, and tolerance are known to occur with codeine.

Read the entire FDA prescribing information for Phenergan-Codeine (Codeine Phosphate and Promethazine HCl)

© Phenergan-Codeine Patient Information is supplied by Cerner Multum, Inc. and Phenergan-Codeine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors