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Phenergan

Last reviewed on RxList: 6/23/2020
Phenergan Side Effects Center

What Is Phenergan?

Phenergan (promethazine HCI) is an antihistamine used to treat nausea and vomiting related to certain conditions (e.g., motion sickness, before/after surgery). Phenergan is also used to treat allergic symptoms such as rash, itching, and runny nose. The brand name Phenergan is discontinued in the U.S. Phenergan is available as a generic drug.

What Are Side Effects of Phenergan?

Common side effects of Phenergan (promethazine HCI) include

Dosage for Phenergan

The dose of Phenergan to treat allergies is 25 mg taken before retiring. The adult dose of Phenergan to treat motion sickness is 25 mg taken twice daily. The dose of Phenergan for the active therapy of nausea and vomiting in children or adults is 25 mg.

What Drugs, Substances, or Supplements Interact with Phenergan?

Phenergan may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, seizure medications, antidepressants, anxiety medicines, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome medications, medicines to treat pituitary gland tumor, or medicines to treat stomach ulcer or irritable bowel syndrome. Tell your doctor all medications and supplements you use.

Phenergan During Pregnancy and Breastfeeding

Phenergan Tablets and Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Phenergan is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Phenergan Tablets and Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Additional Information

Our Phenergan Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Phenergan Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using promethazine and call your doctor at once if you have:

  • severe drowsiness, weak or shallow breathing;
  • a light-headed feeling, like you might pass out;
  • confusion, agitation, hallucinations, nightmares;
  • seizure (convulsions);
  • fast or slow heartbeats;
  • jaundice (yellowing of the skin or eyes);
  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Side effects such as confusion and severe drowsiness may be more likely in older adults.

Common side effects may include:

  • drowsiness, dizziness;
  • ringing in your ears;
  • double vision;
  • feeling nervous;
  • dry mouth; or
  • tired feeling, sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Phenergan (Promethazine)

QUESTION

Allergies can best be described as: See Answer
Phenergan Professional Information

SIDE EFFECTS

Central Nervous System

Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular – Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic – Dermatitis, photosensitivity, urticaria.

Hematologic – Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal – Dry mouth, nausea, vomiting, jaundice.

Respiratory – Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). (See WARNINGS Respiratory Depression).

Other – Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported (See WARNINGSNeuroleptic Malignant Syndrome).

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.

To report SUSPECTED ADVERSE REACTIONS, contact Renaissance Pharma, Inc. at 1-866-897-5002 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Read the entire FDA prescribing information for Phenergan (Promethazine)

Related Resources for Phenergan

Related Health

Read the Phenergan User Reviews »

© Phenergan Patient Information is supplied by Cerner Multum, Inc. and Phenergan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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