Physostigmine Side Effects Center

Last updated on RxList: 7/25/2022
Physostigmine Side Effects Center

What Is Physostigmine?

Physostigmine Salicylate Injection is an antidote used to reverse the effect of drugs that cause anticholinergic syndrome.

What Are Side Effects of Physostigmine?

Common side effects of physostigmine salicylate include:

  • nausea,
  • vomiting,
  • salivation,
  • stomach cramps,
  • diarrhea, and
  • excessive sweating

What are the possible side effects of Physostigmine?

Physostigmine may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • increased urination or bowel movements,
  • stomach cramps,
  • severe or worsening nausea or vomiting,
  • increased sweating,
  • blurred vision, and
  • excessive saliva in your mouth

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Physostigmine

The recommended dosage of physostigmine salicylate is 0.5 to 1.0 mg.

What Drugs, Substances, or Supplements Interact with Physostigmine?

Other drugs may interact with physostigmine salicylate. Tell your doctor all medications you take. Before taking physostigmine salicylate tell your doctor if you have sulfite sensitivity.

Physostigmine During Pregnancy and Breastfeeding

If you are pregnant or breastfeeding only take physostigmine salicylate if the potential benefits outweigh the potential risks.

Additional Information

Our Physostigmine Salicylate Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Physostigmine Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • increased urination or bowel movements;
  • stomach cramps;
  • severe or worsening nausea or vomiting;
  • increased sweating;
  • blurred vision; or
  • excessive saliva in your mouth.

Common side effects may include:

  • nausea, vomiting;
  • increased salivation; or
  • slow heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Physostigmine Professional Information


Nausea, vomiting and salivation; can be offset by reducing dosage. Bradycardia and convulsions, if intravenous administration is too rapid. See DOSAGE AND ADMINISTRATION

Read the entire FDA prescribing information for Physostigmine (Physostigmine Salicylate (injection))

© Physostigmine Patient Information is supplied by Cerner Multum, Inc. and Physostigmine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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