Pilopine HS

Last updated on RxList: 8/28/2008
Pilopine HS Side Effects Center

Last reviewed on RxList 4/21/2016

Pilopine HS (pilocarpine hydrochloride) Ophthalmic Gel 4% is a cholinergic agent that works by decreasing the amount of fluid within the eye used to treat glaucoma or ocular hypertension (high pressure inside the eye). Common side effects of Pilopine HS include:

  • temporary irritation/burning/stinging/discomfort of the eye
  • temporary blurred vision
  • poor vision in dim or dark light
  • headache, or
  • brow ache

The recommended dose of Pilopine HS is to apply a one-half inch ribbon in the lower conjunctival sac of the affected eye(s) once a day at bedtime. Other drugs may interact with Pilopine HS. Tell your doctor all medications and supplements you use. During pregnancy, Pilopine HS should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Pilopine HS (pilocarpine hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Pilopine HS Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stinging, burning, swelling, or redness of your eye;
  • vision changes;
  • eye pain or increased watering; or
  • signs of eye infection--swelling, redness, severe discomfort, crusting or drainage.

Common side effects may include:

  • headache, eyebrow pain;
  • eye pain or irritation;
  • blurred vision;
  • trouble seeing in low light; or
  • your eyes may be more sensitive to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Pilopine HS (Pilocarpine Hydrochloride Ophthalmic Gel)


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Pilopine HS Professional Information


The following adverse experiences associated with pilocarpine therapy have been reported: lacrimation, burning or discomfort, temporal or periorbital headache, ciliary spasm, conjunctival vascular congestion, superficial keratitis and induced myopia. Systemic reactions following topical administration are extremely rare, but occasional patients are peculiarly sensitive to develop sweating and gastrointestinal overactivity following suggested dosage and administration. Ocular reactions usually occur during initiation of therapy and often will not persist with continued therapy. Reduced visual acuity in poor illumination is frequently experienced in older individuals and in those with lens opacity. A subtle corneal granularity was observed in about 10% of patients treated with PILOPINE HS® (pilocarpine hydrochloride ophthalmic gel) . Cases of retinal detachment have been reported during treatment with miotic agents; especially in young myopic patients. Lens opacity may occur with prolonged use of pilocarpine.

Read the entire FDA prescribing information for Pilopine HS (Pilocarpine Hydrochloride Ophthalmic Gel)

© Pilopine HS Patient Information is supplied by Cerner Multum, Inc. and Pilopine HS Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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